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Analytical electric field and sensitivity analysis for two microfluidic impedance cytometer designs

Analytical electric field and sensitivity analysis for two microfluidic impedance cytometer designs
Analytical electric field and sensitivity analysis for two microfluidic impedance cytometer designs
Microfabricated impedance cytometers have been developed to measure the electrical impedance of single biological particles at high speed. A general approach to analytically solve the electric field distributions for two different designs of cytometers: parallel facing electrodes and coplanar electrodes, using the Schwarz–Christoffel Mapping method is presented. Compared to previous analytical solutions, our derivations are more systematic and solutions are more straightforward. The solutions have been validated by comparison with numerical simulations performed using the finite element method. The influences on the electric field distribution due to the variations in the geometry of the devices have been discussed. A simple method is used to determine the impedance sensitivity of the system and to compare the two electrode designs. For identical geometrical parameters, we conclude that the parallel electrodes design is more sensitive than the coplanar electrodes.
1751-8741
69-79
Sun, Tao
b2f8e932-a7e6-4fe7-94dd-5c4ce725eacb
Green, Nicolas G
d9b47269-c426-41fd-a41d-5f4579faa581
Gawad, Shady
98f746a7-4bcc-42bb-a450-dafda85be29c
Morgan, Hywel
de00d59f-a5a2-48c4-a99a-1d5dd7854174
Sun, Tao
b2f8e932-a7e6-4fe7-94dd-5c4ce725eacb
Green, Nicolas G
d9b47269-c426-41fd-a41d-5f4579faa581
Gawad, Shady
98f746a7-4bcc-42bb-a450-dafda85be29c
Morgan, Hywel
de00d59f-a5a2-48c4-a99a-1d5dd7854174

Sun, Tao, Green, Nicolas G, Gawad, Shady and Morgan, Hywel (2007) Analytical electric field and sensitivity analysis for two microfluidic impedance cytometer designs. IET Nanobiotechnology, 1 (5), 69-79. (doi:10.1049/iet-nbt:20070019).

Record type: Article

Abstract

Microfabricated impedance cytometers have been developed to measure the electrical impedance of single biological particles at high speed. A general approach to analytically solve the electric field distributions for two different designs of cytometers: parallel facing electrodes and coplanar electrodes, using the Schwarz–Christoffel Mapping method is presented. Compared to previous analytical solutions, our derivations are more systematic and solutions are more straightforward. The solutions have been validated by comparison with numerical simulations performed using the finite element method. The influences on the electric field distribution due to the variations in the geometry of the devices have been discussed. A simple method is used to determine the impedance sensitivity of the system and to compare the two electrode designs. For identical geometrical parameters, we conclude that the parallel electrodes design is more sensitive than the coplanar electrodes.

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Published date: 2007
Organisations: Electronics & Computer Science

Identifiers

Local EPrints ID: 264424
URI: https://eprints.soton.ac.uk/id/eprint/264424
ISSN: 1751-8741
PURE UUID: 7fba18c1-d7ed-40bc-8cc3-6617d50fe2b7
ORCID for Nicolas G Green: ORCID iD orcid.org/0000-0001-9230-4455
ORCID for Hywel Morgan: ORCID iD orcid.org/0000-0003-4850-5676

Catalogue record

Date deposited: 21 Aug 2007
Last modified: 17 Sep 2019 00:52

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