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Micromachined glass apertures for artificial lipid bilayer formation in a microfluidic system

Micromachined glass apertures for artificial lipid bilayer formation in a microfluidic system
Micromachined glass apertures for artificial lipid bilayer formation in a microfluidic system
The use of spark assisted chemical engraving (SACE) to produce glass apertures that are suitable for the formation of artificial bilayer lipid membranes is described. Prior to use, the glass apertures were rendered hydrophobic by a silanization process and were then incorporated into a simple microfluidic device. Successful bilayer lipid membrane (BLM) formation and the subsequent acquisition of single-channel recordings are demonstrated. Due to the simplicity and rapidity of the SACE process, these glass apertures could be easily integrated into an all-glass microfluidic system for BLM formation.
0960-1317
S189-S196
Sandison, M.E.
fe8a3953-a4d6-4c24-a959-ea6c8ec43aed
Zagnoni, M.
c719a8d2-cd85-4d22-a669-eb0557b3aa95
Abu-Hantash, M.
445fd4d9-0b65-491a-a128-0007f2619367
Morgan, H.
de00d59f-a5a2-48c4-a99a-1d5dd7854174
Sandison, M.E.
fe8a3953-a4d6-4c24-a959-ea6c8ec43aed
Zagnoni, M.
c719a8d2-cd85-4d22-a669-eb0557b3aa95
Abu-Hantash, M.
445fd4d9-0b65-491a-a128-0007f2619367
Morgan, H.
de00d59f-a5a2-48c4-a99a-1d5dd7854174

Sandison, M.E., Zagnoni, M., Abu-Hantash, M. and Morgan, H. (2007) Micromachined glass apertures for artificial lipid bilayer formation in a microfluidic system. Journal of Micromechanics and Microengineering, 17, S189-S196.

Record type: Article

Abstract

The use of spark assisted chemical engraving (SACE) to produce glass apertures that are suitable for the formation of artificial bilayer lipid membranes is described. Prior to use, the glass apertures were rendered hydrophobic by a silanization process and were then incorporated into a simple microfluidic device. Successful bilayer lipid membrane (BLM) formation and the subsequent acquisition of single-channel recordings are demonstrated. Due to the simplicity and rapidity of the SACE process, these glass apertures could be easily integrated into an all-glass microfluidic system for BLM formation.

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More information

Published date: 2007
Organisations: Nanoelectronics and Nanotechnology

Identifiers

Local EPrints ID: 264501
URI: https://eprints.soton.ac.uk/id/eprint/264501
ISSN: 0960-1317
PURE UUID: 8e9652ac-117f-4937-aed1-fbbe54be5765
ORCID for H. Morgan: ORCID iD orcid.org/0000-0003-4850-5676

Catalogue record

Date deposited: 14 Sep 2007
Last modified: 17 Sep 2019 00:52

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