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Air-Exposure Technique for the Formation of Artificial Lipid Bilayers in Microsystems

Record type: Article

To develop a reliable method for on-chip bilayer lipid membrane (BLM) formation, which could be employed for use in a biosensor array platform, a polymer microfluidic device has been constructed, and the formation of suspended BLMs within it has been investigated. A simple, yet reproducible BLM formation protocol has been developed, in which a brief air-exposure period is employed to induce the rapid thinning of an initially thick lipid-solvent layer. The technique is rapid, reproducible, and amenable to the simple injection of proteins or analytes, as well as to buffer exchange on both sides of the membrane. Scaling up the technique for use in an array platform is also straightforward, the simultaneous formation of three individually addressable BLMs being demonstrated.

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Citation

Sandison, M.E., Zagnoni, M. and Morgan, H. (2007) Air-Exposure Technique for the Formation of Artificial Lipid Bilayers in Microsystems Langmuir, 23, pp. 8277-8284.

More information

Published date: 2007
Organisations: Nanoelectronics and Nanotechnology

Identifiers

Local EPrints ID: 264502
URI: http://eprints.soton.ac.uk/id/eprint/264502
ISSN: 0743-7463
PURE UUID: e7abe148-eff2-4e1e-ac12-471fbb5ef5fa
ORCID for H. Morgan: ORCID iD orcid.org/0000-0003-4850-5676

Catalogue record

Date deposited: 14 Sep 2007
Last modified: 18 Jul 2017 07:34

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Contributors

Author: M.E. Sandison
Author: M. Zagnoni
Author: H. Morgan ORCID iD

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