Idiotype gene rescue in follicular lymphoma
Idiotype gene rescue in follicular lymphoma
Beyond the morphological, immunophenotypic, and genetic information used for the diagnosis of lymphoid malignancies, molecular analyses have deepened our insights into the development of B-cell lymphomas. We have learned that B-cell tumors can be grouped according to the mutational status of their immunoglobulin variable (V) region genes, and this has become an important prognostic tool in chronic lymphocytic leukemia. The analysis of V genes also has allowed us to more precisely place B-cell lymphomas relative to their normal B-cell counterparts and to the germinal center where somatic hypermutation takes place. It has become evident that many of the common B-cell tumors arise at this site and are able to respond to stimuli, which govern normal B-cells. In this chapter, we focus on the analysis of V genes in follicular lymphomas based on the experience in our laboratory and provide a detailed guide for this analysis.
follicular lymphoma, non-hodgkin's lymphoma, immunoglobulin, v-gene analysis, immunogenetics, pcr, sequencing, cloning
1-59259-936-2
145-171
McCann, Katy
2f58a345-4009-42e5-aa6e-e74d512beae8
Sahota, Surinder S.
66c1457f-cba2-4c49-9c8c-fcee0748b6b8
Stevenson, Freda K.
ba803747-c0ac-409f-a9c2-b61fde009f8c
Ottensmeier, Christian H.
42b8a398-baac-4843-a3d6-056225675797
2005
McCann, Katy
2f58a345-4009-42e5-aa6e-e74d512beae8
Sahota, Surinder S.
66c1457f-cba2-4c49-9c8c-fcee0748b6b8
Stevenson, Freda K.
ba803747-c0ac-409f-a9c2-b61fde009f8c
Ottensmeier, Christian H.
42b8a398-baac-4843-a3d6-056225675797
McCann, Katy, Sahota, Surinder S., Stevenson, Freda K. and Ottensmeier, Christian H.
(2005)
Idiotype gene rescue in follicular lymphoma.
In,
Lymphoma: methods and protocols.
(Methods in Molecular Medicine, 115)
Humana Press, .
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Book Section
Abstract
Beyond the morphological, immunophenotypic, and genetic information used for the diagnosis of lymphoid malignancies, molecular analyses have deepened our insights into the development of B-cell lymphomas. We have learned that B-cell tumors can be grouped according to the mutational status of their immunoglobulin variable (V) region genes, and this has become an important prognostic tool in chronic lymphocytic leukemia. The analysis of V genes also has allowed us to more precisely place B-cell lymphomas relative to their normal B-cell counterparts and to the germinal center where somatic hypermutation takes place. It has become evident that many of the common B-cell tumors arise at this site and are able to respond to stimuli, which govern normal B-cells. In this chapter, we focus on the analysis of V genes in follicular lymphomas based on the experience in our laboratory and provide a detailed guide for this analysis.
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Published date: 2005
Keywords:
follicular lymphoma, non-hodgkin's lymphoma, immunoglobulin, v-gene analysis, immunogenetics, pcr, sequencing, cloning
Identifiers
Local EPrints ID: 26465
URI: http://eprints.soton.ac.uk/id/eprint/26465
ISBN: 1-59259-936-2
PURE UUID: 203a01ad-17e6-4118-9545-e39ced8d5f79
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Date deposited: 21 Apr 2006
Last modified: 23 Jul 2022 01:41
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Contributors
Author:
Katy McCann
Author:
Surinder S. Sahota
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