The University of Southampton
University of Southampton Institutional Repository

The effect of cholecystectomy on plasma cholecystokinin

The effect of cholecystectomy on plasma cholecystokinin
The effect of cholecystectomy on plasma cholecystokinin
Objective: Gallbladder removal is associated with an increased incidence of gastroesophageal reflux, but the mechanism is unclear. Cholecystokinin (CCK) release, which causes gallbladder contraction, is inhibited by bile in the duodenum. This study investigates the effect of cholecystectomy on meal-stimulated CCK secretion.
Methods: Three groups of patients were studied. Group 1 (n = 15) were normal controls. Group 2 (n = 27) were patients with symptomatic gallstones. Group 3 (n = 25) were patients who had undergone cholecystectomy. Meal-stimulated CCK levels were measured by radioimmunoassay at defined time points for 60 min after a standard corn oil-based meal.
Results: Fasting CCK levels were similar in all three groups. In postcholecystectomy patients, meal-stimulated plasma CCK levels were significantly elevated compared with controls: median (range) integrated CCK values for 60 min were 116 (28–209) in controls, 123 (20–501) in gallstone patients, and 176 (63–502) after cholecystectomy.
Conclusions: This study suggests that cholecystectomy causes an exaggerated meal-stimulated CCK response. Because CCK is known to relax the lower esophageal sphincter, these findings may help explain the increased incidence of gastroesophageal reflux seen after cholecystectomy.
0002-9270
2189-2192
McDonnell, Ciaran O.
2184bf42-1929-4794-ade6-bae9ee717e00
Bailey, Ian
635ff85d-4492-45be-bdf5-b54a2762a703
Stumpf, Thomas
39bb4977-27d0-483d-b01b-8b413a37d55a
Walsh, Thomas N.
136fff5b-88be-40ae-acde-b9577dc8510e
Johnson, Coiln D.
e50aa9cd-8c61-4fe3-a0b3-f51cc3a6c74a
McDonnell, Ciaran O.
2184bf42-1929-4794-ade6-bae9ee717e00
Bailey, Ian
635ff85d-4492-45be-bdf5-b54a2762a703
Stumpf, Thomas
39bb4977-27d0-483d-b01b-8b413a37d55a
Walsh, Thomas N.
136fff5b-88be-40ae-acde-b9577dc8510e
Johnson, Coiln D.
e50aa9cd-8c61-4fe3-a0b3-f51cc3a6c74a

McDonnell, Ciaran O., Bailey, Ian, Stumpf, Thomas, Walsh, Thomas N. and Johnson, Coiln D. (2002) The effect of cholecystectomy on plasma cholecystokinin. American Journal of Gastroenterology, 97 (9), 2189-2192. (doi:10.1111/j.1572-0241.2002.05971.x).

Record type: Article

Abstract

Objective: Gallbladder removal is associated with an increased incidence of gastroesophageal reflux, but the mechanism is unclear. Cholecystokinin (CCK) release, which causes gallbladder contraction, is inhibited by bile in the duodenum. This study investigates the effect of cholecystectomy on meal-stimulated CCK secretion.
Methods: Three groups of patients were studied. Group 1 (n = 15) were normal controls. Group 2 (n = 27) were patients with symptomatic gallstones. Group 3 (n = 25) were patients who had undergone cholecystectomy. Meal-stimulated CCK levels were measured by radioimmunoassay at defined time points for 60 min after a standard corn oil-based meal.
Results: Fasting CCK levels were similar in all three groups. In postcholecystectomy patients, meal-stimulated plasma CCK levels were significantly elevated compared with controls: median (range) integrated CCK values for 60 min were 116 (28–209) in controls, 123 (20–501) in gallstone patients, and 176 (63–502) after cholecystectomy.
Conclusions: This study suggests that cholecystectomy causes an exaggerated meal-stimulated CCK response. Because CCK is known to relax the lower esophageal sphincter, these findings may help explain the increased incidence of gastroesophageal reflux seen after cholecystectomy.

Full text not available from this repository.

More information

Published date: 2002

Identifiers

Local EPrints ID: 26468
URI: http://eprints.soton.ac.uk/id/eprint/26468
ISSN: 0002-9270
PURE UUID: d1cf2fc6-b301-478b-be73-1c0e952f3d44

Catalogue record

Date deposited: 21 Apr 2006
Last modified: 15 Jul 2019 19:14

Export record

Altmetrics

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×