Biophysical studies of a transmembrane peptide derived from the T cell antigen receptor

Ali, M, de Planque, M R R, Huynh, N T, Manolios, N and Separovic, F (2002) Biophysical studies of a transmembrane peptide derived from the T cell antigen receptor International Journal of Peptide Research and Therapeutics, 8, (3-5), pp. 227-233. (doi:10.1007/BF02446521).


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Core peptide (CP) is a unique peptide derived from the transmembrane sequence of T cell antigen receptor (TCR)-alpha chain and is capable of inhibiting the immune response both invitro and in animal models of T cell mediated inflammation. The structure of CP, with sequence GLRILLLKV, is similar to the amphipathic region of many peptides. Unlike antimicrobial peptides, however, which damage cell membranes, electron microscopy and propidium iodide exclusion assays on cell membranes suggest that CP does not create pores and may act by interfering with signal transduction at the membrane level. To investigate this effect further we report the results of31P and2H solid-state NMR spectroscopy of CP on model membranes. As predicted, even at high concentrations of CP, the structure of model membranes was not significantly perturbed. Only at the very high peptide-to-lipid molar ratio of 1?10 significant effects on the model membranes were observed. We conclude that CP does not destroy the integrity of the lipid bilayer.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1007/BF02446521
ISSNs: 1573-3149 (print)
Keywords: 2H NMR - 31P NMR - T cell antigen receptor - CD - lipid bilayer
Organisations: Nanoelectronics and Nanotechnology
ePrint ID: 264695
Date :
Date Event
Date Deposited: 17 Oct 2007
Last Modified: 17 Apr 2017 19:32
Further Information:Google Scholar

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