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Immunohistochemical analysis of the antiapoptotic Mcl-1 and Bcl-2 proteins in follicular lymphoma

Immunohistochemical analysis of the antiapoptotic Mcl-1 and Bcl-2 proteins in follicular lymphoma
Immunohistochemical analysis of the antiapoptotic Mcl-1 and Bcl-2 proteins in follicular lymphoma
In the present study, we investigated the expression of Mcl-1 and Bcl-2 by immunohistochemistry in 85 patients of grades 1–3 and transformed follicular lymphoma (FL). In lymphoma tissue, centroblasts uniformly expressed high levels of Mcl-1 (Mcl-1hi) whereas centrocytes demonstrated low Mcl-1 expression (Mcl-1lo). Bcl-2 expression in centroblasts/centrocytes was reciprocal to Mcl-1 staining in most cases. A high number of Mcl-1hi centroblasts in tissue sections (?200/high-power field) correlated with poor overall survival (P < 0·001), independent of the International Prognostic Index and FL grade. This suggests that the number of centroblasts with strong Mcl-1 staining is associated with clinical outcome in FL patients.
mcl-1, bcl-2, follicular lymphoma, grading
0007-1048
743-746
Michels, J.
01124646-b096-4cec-86c9-2cbddaad8e74
Foria, V.
eb057891-e35c-4e2f-98b7-43202e310352
Mead, B.
94106b0d-3362-4fca-b601-bf0ad5a09d0e
Jackson, G.
cfad63dd-007d-4470-8130-2e57d931ab2e
Mullee, M.
fd3f91c3-5e95-4f56-8d73-260824eeb362
Johnson, P.W.
e01f93bd-4ce9-473a-991c-b770f4a6029b
Packham, G.
fdabe56f-2c58-469c-aadf-38878f233394
Michels, J.
01124646-b096-4cec-86c9-2cbddaad8e74
Foria, V.
eb057891-e35c-4e2f-98b7-43202e310352
Mead, B.
94106b0d-3362-4fca-b601-bf0ad5a09d0e
Jackson, G.
cfad63dd-007d-4470-8130-2e57d931ab2e
Mullee, M.
fd3f91c3-5e95-4f56-8d73-260824eeb362
Johnson, P.W.
e01f93bd-4ce9-473a-991c-b770f4a6029b
Packham, G.
fdabe56f-2c58-469c-aadf-38878f233394

Michels, J., Foria, V., Mead, B., Jackson, G., Mullee, M., Johnson, P.W. and Packham, G. (2006) Immunohistochemical analysis of the antiapoptotic Mcl-1 and Bcl-2 proteins in follicular lymphoma. British Journal of Haematology, 132 (6), 743-746. (doi:10.1111/j.1365-2141.2005.05954.x).

Record type: Article

Abstract

In the present study, we investigated the expression of Mcl-1 and Bcl-2 by immunohistochemistry in 85 patients of grades 1–3 and transformed follicular lymphoma (FL). In lymphoma tissue, centroblasts uniformly expressed high levels of Mcl-1 (Mcl-1hi) whereas centrocytes demonstrated low Mcl-1 expression (Mcl-1lo). Bcl-2 expression in centroblasts/centrocytes was reciprocal to Mcl-1 staining in most cases. A high number of Mcl-1hi centroblasts in tissue sections (?200/high-power field) correlated with poor overall survival (P < 0·001), independent of the International Prognostic Index and FL grade. This suggests that the number of centroblasts with strong Mcl-1 staining is associated with clinical outcome in FL patients.

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Published date: 2006
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Keywords: mcl-1, bcl-2, follicular lymphoma, grading

Identifiers

Local EPrints ID: 26483
URI: http://eprints.soton.ac.uk/id/eprint/26483
DOI: doi:10.1111/j.1365-2141.2005.05954.x
ISSN: 0007-1048
PURE UUID: cdecc9fd-2a04-429b-9a71-afea3b3ed11b
ORCID for G. Packham: ORCID iD orcid.org/0000-0002-9232-5691

Catalogue record

Date deposited: 07 Apr 2006
Last modified: 16 Mar 2024 03:14

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Contributors

Author: J. Michels
Author: V. Foria
Author: B. Mead
Author: G. Jackson
Author: M. Mullee
Author: P.W. Johnson
Author: G. Packham ORCID iD

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