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Smoking and the risk of acute myeloid leukaemia in cytogenetic subgroups

Moorman, A.V., Roman, E., Cartwright, R.A. and Morgan, G.J. (2002) Smoking and the risk of acute myeloid leukaemia in cytogenetic subgroups British Journal of Cancer, 86, (1), pp. 60-62. (doi:10.1038/sj/bjc/6600010).

Record type: Article


Cytogenetically-defined subgroups of acute myeloid leukaemia have distinct biologies, clinical features and outcomes. Evidence from therapy-related leukaemia suggests that chromosomal abnormalities are also markers of exposure. Our results suggest that the smoking-associated risk for acute myeloid leukaemia is restricted to the t(8;21)(q22;q22) subgroup. This supports the hypothesis that distinct cytogenetic subgroups of acute myeloid leukaemia have separate aetiologies.

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Published date: 2002
Keywords: cytogenetics, chromosomal abnormalities, tobacco smoke, acute myeloid leukaemia, aetiology


Local EPrints ID: 26495
ISSN: 0007-0920
PURE UUID: 2c39dbac-ba97-4faf-90d9-a604a1a47604

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Date deposited: 12 Apr 2006
Last modified: 17 Jul 2017 16:07

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Author: A.V. Moorman
Author: E. Roman
Author: R.A. Cartwright
Author: G.J. Morgan

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