Moorman, A.V., Roman, E., Cartwright, R.A. and Morgan, G.J.
Smoking and the risk of acute myeloid leukaemia in cytogenetic subgroups
British Journal of Cancer, 86, (1), . (doi:10.1038/sj/bjc/6600010).
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Cytogenetically-defined subgroups of acute myeloid leukaemia have distinct biologies, clinical features and outcomes. Evidence from therapy-related leukaemia suggests that chromosomal abnormalities are also markers of exposure. Our results suggest that the smoking-associated risk for acute myeloid leukaemia is restricted to the t(8;21)(q22;q22) subgroup. This supports the hypothesis that distinct cytogenetic subgroups of acute myeloid leukaemia have separate aetiologies.
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