Smoking and the risk of acute myeloid leukaemia in cytogenetic subgroups
Smoking and the risk of acute myeloid leukaemia in cytogenetic subgroups
Cytogenetically-defined subgroups of acute myeloid leukaemia have distinct biologies, clinical features and outcomes. Evidence from therapy-related leukaemia suggests that chromosomal abnormalities are also markers of exposure. Our results suggest that the smoking-associated risk for acute myeloid leukaemia is restricted to the t(8;21)(q22;q22) subgroup. This supports the hypothesis that distinct cytogenetic subgroups of acute myeloid leukaemia have separate aetiologies.
cytogenetics, chromosomal abnormalities, tobacco smoke, acute myeloid leukaemia, aetiology
60-62
Moorman, A.V.
af5027f3-4927-4e62-b1be-ac4bdcf6cd8f
Roman, E.
5f184e94-d01d-40b5-8cbe-6dd6335a850b
Cartwright, R.A.
d01c44b2-1973-4016-910f-5aea98cb73fe
Morgan, G.J.
7e5206cc-8a58-410c-9ea5-9022b1532ace
2002
Moorman, A.V.
af5027f3-4927-4e62-b1be-ac4bdcf6cd8f
Roman, E.
5f184e94-d01d-40b5-8cbe-6dd6335a850b
Cartwright, R.A.
d01c44b2-1973-4016-910f-5aea98cb73fe
Morgan, G.J.
7e5206cc-8a58-410c-9ea5-9022b1532ace
Moorman, A.V., Roman, E., Cartwright, R.A. and Morgan, G.J.
(2002)
Smoking and the risk of acute myeloid leukaemia in cytogenetic subgroups.
British Journal of Cancer, 86 (1), .
(doi:10.1038/sj/bjc/6600010).
Abstract
Cytogenetically-defined subgroups of acute myeloid leukaemia have distinct biologies, clinical features and outcomes. Evidence from therapy-related leukaemia suggests that chromosomal abnormalities are also markers of exposure. Our results suggest that the smoking-associated risk for acute myeloid leukaemia is restricted to the t(8;21)(q22;q22) subgroup. This supports the hypothesis that distinct cytogenetic subgroups of acute myeloid leukaemia have separate aetiologies.
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Published date: 2002
Keywords:
cytogenetics, chromosomal abnormalities, tobacco smoke, acute myeloid leukaemia, aetiology
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Local EPrints ID: 26495
URI: http://eprints.soton.ac.uk/id/eprint/26495
ISSN: 0007-0920
PURE UUID: 2c39dbac-ba97-4faf-90d9-a604a1a47604
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Date deposited: 12 Apr 2006
Last modified: 15 Mar 2024 07:11
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Author:
A.V. Moorman
Author:
E. Roman
Author:
R.A. Cartwright
Author:
G.J. Morgan
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