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Disturbances in peripheral blood B cell subpopulations in autoimmune patients

Disturbances in peripheral blood B cell subpopulations in autoimmune patients
Disturbances in peripheral blood B cell subpopulations in autoimmune patients
A variety of cell surface markers are being used to identify B cell subpopulations in peripheral blood. Currently at least eight subpopulations have been identified. Analyses of healthy individuals indicate that in general the various B cell subpopulations exist in relatively similar ratios in unrelated individuals. It has been demonstrated that B lymphocyte homeostasis is disturbed during infection and autoimmune disease. In this review we compare the distribution of B cell subpopulations in the peripheral blood of patients with systemic lupus erythematosus, rheumatoid arthritis and primary Sjogren's syndrome with each other, and with healthy individuals. The different autoimmune diseases have distinct changes in the B cell subpopulations. Understanding the nature of these B subpopulation signatures will potentially impact understanding the mechanisms of disease, diagnosis and therapy.
872-877
Potter, K.N.
86a99047-494b-405b-a3f7-650c1dcd5838
Mockridge, C.I.
327aef17-4837-4f2a-a93b-3d17cd1a7f9f
Rahman, A.
a872c919-e0e1-4af7-a61f-749c5d652242
Buchan, S.
9ade187d-f127-45de-ad90-9d544d64718a
Hamblin, T.
50cc753a-132d-4f62-91a5-a53f6c4c022c
Davidson, B.
1a3f15c8-5e74-4551-9d18-6c41448b65af
Isenberg, D.A.
fd0b0405-1800-4680-89f1-564c023ceb10
Stevenson, F.K.
ba803747-c0ac-409f-a9c2-b61fde009f8c
Potter, K.N.
86a99047-494b-405b-a3f7-650c1dcd5838
Mockridge, C.I.
327aef17-4837-4f2a-a93b-3d17cd1a7f9f
Rahman, A.
a872c919-e0e1-4af7-a61f-749c5d652242
Buchan, S.
9ade187d-f127-45de-ad90-9d544d64718a
Hamblin, T.
50cc753a-132d-4f62-91a5-a53f6c4c022c
Davidson, B.
1a3f15c8-5e74-4551-9d18-6c41448b65af
Isenberg, D.A.
fd0b0405-1800-4680-89f1-564c023ceb10
Stevenson, F.K.
ba803747-c0ac-409f-a9c2-b61fde009f8c

Potter, K.N., Mockridge, C.I., Rahman, A., Buchan, S., Hamblin, T., Davidson, B., Isenberg, D.A. and Stevenson, F.K. (2002) Disturbances in peripheral blood B cell subpopulations in autoimmune patients. Lupus, 11 (12), 872-877.

Record type: Article

Abstract

A variety of cell surface markers are being used to identify B cell subpopulations in peripheral blood. Currently at least eight subpopulations have been identified. Analyses of healthy individuals indicate that in general the various B cell subpopulations exist in relatively similar ratios in unrelated individuals. It has been demonstrated that B lymphocyte homeostasis is disturbed during infection and autoimmune disease. In this review we compare the distribution of B cell subpopulations in the peripheral blood of patients with systemic lupus erythematosus, rheumatoid arthritis and primary Sjogren's syndrome with each other, and with healthy individuals. The different autoimmune diseases have distinct changes in the B cell subpopulations. Understanding the nature of these B subpopulation signatures will potentially impact understanding the mechanisms of disease, diagnosis and therapy.

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More information

Published date: 2002

Identifiers

Local EPrints ID: 26536
URI: http://eprints.soton.ac.uk/id/eprint/26536
PURE UUID: d991de59-7fb7-4c61-95ca-98b5e377e091
ORCID for F.K. Stevenson: ORCID iD orcid.org/0000-0002-0933-5021

Catalogue record

Date deposited: 12 Apr 2006
Last modified: 17 Dec 2019 01:57

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