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Transplantation treatment of spinal cord injury patients

Transplantation treatment of spinal cord injury patients
Transplantation treatment of spinal cord injury patients
The minimally manipulated cells from fetal nervous and hemopoietic tissues (gestational age 16–22 weeks) were subarachnoidally implanted into 15 patients (18–52 years old) with severe consequences of traumatic spinal cord injury (SCI) at cervical or thoracic spine level. The times after SCI were from 1 month to 6 years. Each patient underwent from one to four cell transplantations (CT) with various time intervals. In 11 of 15 cases, CT was combined with an operative partial disruption of a connective tissue cyst and with implantation into a spinal cord lesion of a spinal cord fragment together with olfactory ensheathing cells. Before CT the patients showed complete motor and sensory function disorder consistent with a grade A of SCI according to Frankel classification. With CT treatment, six patients improved their neurological status from A to C grade of SCI, exhibiting incomplete restoration of both motor and sensory function. The status of other five CT-treated patients became consistent with SCI grade B and was characterized by appearance of contracting activity in some muscles and incomplete restoration of sensitivity. The remaining four patients did not exhibit any clinical improvements. No serious complications of CT were noted. The results suggest a clinical relevance of the CT-based approach to treating severe consequences of SCI.
spinal cord injury, cell transplantation
428-433
Rabinovich, Samuil S.
dbe77a48-3890-44af-959c-284599708f78
Seledtsov, Victor I.
cff5037d-06e9-4787-88b0-c85caf546811
Poveschenko, Olga V.
3e11dde5-6dc4-41aa-b2c0-69d0d52dfc1d
Senuykov, Vladimir V.
55a8e885-2207-496a-8f4c-2099b39fbe2e
Taraban, Vadim Ya
a887dd30-fff4-4480-aea3-9ba91a567346
Yarochno, Vladimir I.
8a3241e1-2f81-429f-a3d9-df33ad9b170a
Kolosov, Nicolay G.
91c1b968-43b8-4b78-9990-e27fcfd4973f
Savchenko, Sergey A.
89ad65d4-8036-4ec0-a2ad-5349184af61e
Kozlov, Vladimir A.
158ab978-bab0-49d4-b823-18656f77fab7
Rabinovich, Samuil S.
dbe77a48-3890-44af-959c-284599708f78
Seledtsov, Victor I.
cff5037d-06e9-4787-88b0-c85caf546811
Poveschenko, Olga V.
3e11dde5-6dc4-41aa-b2c0-69d0d52dfc1d
Senuykov, Vladimir V.
55a8e885-2207-496a-8f4c-2099b39fbe2e
Taraban, Vadim Ya
a887dd30-fff4-4480-aea3-9ba91a567346
Yarochno, Vladimir I.
8a3241e1-2f81-429f-a3d9-df33ad9b170a
Kolosov, Nicolay G.
91c1b968-43b8-4b78-9990-e27fcfd4973f
Savchenko, Sergey A.
89ad65d4-8036-4ec0-a2ad-5349184af61e
Kozlov, Vladimir A.
158ab978-bab0-49d4-b823-18656f77fab7

Rabinovich, Samuil S., Seledtsov, Victor I., Poveschenko, Olga V., Senuykov, Vladimir V., Taraban, Vadim Ya, Yarochno, Vladimir I., Kolosov, Nicolay G., Savchenko, Sergey A. and Kozlov, Vladimir A. (2003) Transplantation treatment of spinal cord injury patients. Biomedicine & Pharmacotherapy, 57 (9), 428-433. (doi:10.1016/j.biopha.2003.05.001).

Record type: Article

Abstract

The minimally manipulated cells from fetal nervous and hemopoietic tissues (gestational age 16–22 weeks) were subarachnoidally implanted into 15 patients (18–52 years old) with severe consequences of traumatic spinal cord injury (SCI) at cervical or thoracic spine level. The times after SCI were from 1 month to 6 years. Each patient underwent from one to four cell transplantations (CT) with various time intervals. In 11 of 15 cases, CT was combined with an operative partial disruption of a connective tissue cyst and with implantation into a spinal cord lesion of a spinal cord fragment together with olfactory ensheathing cells. Before CT the patients showed complete motor and sensory function disorder consistent with a grade A of SCI according to Frankel classification. With CT treatment, six patients improved their neurological status from A to C grade of SCI, exhibiting incomplete restoration of both motor and sensory function. The status of other five CT-treated patients became consistent with SCI grade B and was characterized by appearance of contracting activity in some muscles and incomplete restoration of sensitivity. The remaining four patients did not exhibit any clinical improvements. No serious complications of CT were noted. The results suggest a clinical relevance of the CT-based approach to treating severe consequences of SCI.

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More information

Published date: 2003
Keywords: spinal cord injury, cell transplantation

Identifiers

Local EPrints ID: 26547
URI: http://eprints.soton.ac.uk/id/eprint/26547
PURE UUID: 5b6ead80-e9c7-4ec6-bb9e-17a7a2b3dc1d

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Date deposited: 19 Apr 2006
Last modified: 15 Mar 2024 07:11

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Contributors

Author: Samuil S. Rabinovich
Author: Victor I. Seledtsov
Author: Olga V. Poveschenko
Author: Vladimir V. Senuykov
Author: Vadim Ya Taraban
Author: Vladimir I. Yarochno
Author: Nicolay G. Kolosov
Author: Sergey A. Savchenko
Author: Vladimir A. Kozlov

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