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Phase II study of ISIS 3521, an antisense oligodeoxynucleotide to protein kinase C alpha, in patients with previously treated low-grade non-Hodgkin's lymphoma

Rao, S., Watkins, D., Cunningham, D., Dunlop, D., Johnson, P., Selby, P., Hancock, B.W., Fegan, C., Culligan, D., Schey, S., Morris, T.C.M., Lissitchkov, T., Oliver, J.W. and Holmlund, J.T. (2004) Phase II study of ISIS 3521, an antisense oligodeoxynucleotide to protein kinase C alpha, in patients with previously treated low-grade non-Hodgkin's lymphoma Annals of Oncology, 15, (9), pp. 1413-1418. (doi:10.1093/annonc/mdh359).

Record type: Article


Background: The purpose of this study was to assess the efficacy and safety of ISIS 3521, an antisense phosphorothioate oligonucleotide to protein kinase C {alpha} in patients with relapsed low-grade non-Hodgkin's lymphoma (NHL).
Patients and methods: Twenty-six patients received ISIS 3521 (2 mg/kg/day) as a continuous infusion over 21 days of each 28-day cycle.
Results: The median age of the patients was 53 years (range 37–77). Histological subtypes were low-grade follicular lymphoma (n=22) and B-cell small lymphocytic lymphoma (n=4). Twenty-one (81%) had stage III/IV disease. The median number of previous lines of chemotherapy was two (range one to six). A total of 87 cycles of ISIS 3521 were administered. Twenty-three patients were assessable for response. Three patients achieved a partial response. No complete responses were observed. Ten patients had stable disease. Grade 3–4 toxicity was as follows: neutropenia (3.8%) and thrombocytopenia (26.9%).
Conclusions: ISIS 3521 has demonstrated anti-tumour activity in patients with relapsed low-grade NHL. There may be a potential role for this agent in combination with conventional chemotherapy for advanced low-grade lymphoma, and further trials are warranted.

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Published date: 2004
Additional Information: ISI:000223868600015
Keywords: antisense, follicular, non-Hodgkin's lymphoma, treatment
Organisations: Cancer Sciences


Local EPrints ID: 26552
ISSN: 0923-7534
PURE UUID: aacb6e42-07b0-4225-8eb6-f8773c2cfa5b
ORCID for P. Johnson: ORCID iD

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Date deposited: 20 Apr 2006
Last modified: 17 Jul 2017 16:07

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Author: S. Rao
Author: D. Watkins
Author: D. Cunningham
Author: D. Dunlop
Author: P. Johnson ORCID iD
Author: P. Selby
Author: B.W. Hancock
Author: C. Fegan
Author: D. Culligan
Author: S. Schey
Author: T.C.M. Morris
Author: T. Lissitchkov
Author: J.W. Oliver
Author: J.T. Holmlund

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