t(14;19)(q32;q13): a recurrent translocation in B-cell precursor acute lymphoblastic leukemia
t(14;19)(q32;q13): a recurrent translocation in B-cell precursor acute lymphoblastic leukemia
The recurrent t(14;19)(q32;q13) translocation associated with chronic B-cell lymphoproliferative disorders, such as atypical chronic lymphocytic leukemia, results in the juxtaposition of the IGH@ and BCL3 genes and subsequent overexpression of BCL3. We report six patients with B-cell precursor acute lymphoblastic leukemia who have a cytogenetically identical translocation with different breakpoints at the molecular level. Fluorescence in situ hybridization with locus-specific probes confirmed the involvement of the IGH@ gene but showed that the breakpoint on 19q13 lay outside the region documented in t(14;19)(q32;q13)-positive chronic lymphocytic leukemia. This newly described translocation constitutes a distinct cytogenetic subgroup that is confined to older children and younger adults with B-cell precursor acute lymphoblastic leukemia.
88-92
Robinson, Hazel M.
c406aa02-ca17-4ba1-9aa4-24bab6415fc0
Taylor, Kerry E.
f4e3b187-d274-48b1-aca8-661a12741666
Jalali, G. Reza
115b1825-78a7-489b-b4fe-dc846a3df33c
Cheung, Kan Luk
110c6d4d-6f0d-4c96-b207-071dace288d3
Harrison, Christine J.
52da7673-509c-4b88-b92e-0c021c9c7d3e
Moorman, Anthony V.
e4ced178-ee03-47ef-bc5e-25d8453951d5
2004
Robinson, Hazel M.
c406aa02-ca17-4ba1-9aa4-24bab6415fc0
Taylor, Kerry E.
f4e3b187-d274-48b1-aca8-661a12741666
Jalali, G. Reza
115b1825-78a7-489b-b4fe-dc846a3df33c
Cheung, Kan Luk
110c6d4d-6f0d-4c96-b207-071dace288d3
Harrison, Christine J.
52da7673-509c-4b88-b92e-0c021c9c7d3e
Moorman, Anthony V.
e4ced178-ee03-47ef-bc5e-25d8453951d5
Robinson, Hazel M., Taylor, Kerry E., Jalali, G. Reza, Cheung, Kan Luk, Harrison, Christine J. and Moorman, Anthony V.
(2004)
t(14;19)(q32;q13): a recurrent translocation in B-cell precursor acute lymphoblastic leukemia.
Genes, Chromosomes and Cancer, 39 (1), .
(doi:10.1002/gcc.10299).
Abstract
The recurrent t(14;19)(q32;q13) translocation associated with chronic B-cell lymphoproliferative disorders, such as atypical chronic lymphocytic leukemia, results in the juxtaposition of the IGH@ and BCL3 genes and subsequent overexpression of BCL3. We report six patients with B-cell precursor acute lymphoblastic leukemia who have a cytogenetically identical translocation with different breakpoints at the molecular level. Fluorescence in situ hybridization with locus-specific probes confirmed the involvement of the IGH@ gene but showed that the breakpoint on 19q13 lay outside the region documented in t(14;19)(q32;q13)-positive chronic lymphocytic leukemia. This newly described translocation constitutes a distinct cytogenetic subgroup that is confined to older children and younger adults with B-cell precursor acute lymphoblastic leukemia.
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Published date: 2004
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Local EPrints ID: 26573
URI: http://eprints.soton.ac.uk/id/eprint/26573
ISSN: 1045-2257
PURE UUID: e8310a47-44f7-48b7-9b6d-eacb2a1ea40f
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Date deposited: 20 Apr 2006
Last modified: 15 Mar 2024 07:12
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Contributors
Author:
Hazel M. Robinson
Author:
Kerry E. Taylor
Author:
G. Reza Jalali
Author:
Kan Luk Cheung
Author:
Christine J. Harrison
Author:
Anthony V. Moorman
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