NKalpha: Non-uniform epistatic interactions in an extended NK model
NKalpha: Non-uniform epistatic interactions in an extended NK model
Kauffman’s seminal NK model was introduced to relate the properties of fitness landscapes to the extent and nature of epistasis between genes. The original model considered genomes in which the fitness contribution of each of N genes was influenced by the value of K other genes located either at random or from the immediately neighbouring loci on the genome. Both schemes ensure that (on average) every gene is as influential as any other. More recently, the epistatic connectivity between genes in natural genomes has begun to be mapped. The topologies of these genetic networks are neither random nor regular, but exhibit interesting structural properties. The model presented here extends the NK model to consider epistatic network topologies derived from a preferential attachment scheme which tends to ensure that some genes are more influential than others. We explore the consequences of this topology for the properties of the associated fitness landscapes.
234-241
Hebbron, Tom
24aac6f9-0241-48be-a3d8-8468319dc46a
Bullock, Seth
2ad576e4-56b8-4f31-84e0-51bd0b7a1cd3
Cliff, Dave
693f4867-967f-426b-8551-b60c8494ee62
20 May 2008
Hebbron, Tom
24aac6f9-0241-48be-a3d8-8468319dc46a
Bullock, Seth
2ad576e4-56b8-4f31-84e0-51bd0b7a1cd3
Cliff, Dave
693f4867-967f-426b-8551-b60c8494ee62
Hebbron, Tom, Bullock, Seth and Cliff, Dave
(2008)
NKalpha: Non-uniform epistatic interactions in an extended NK model.
Bullock, Seth, Noble, Jason, Watson, Richard and Bedau, Mark A.
(eds.)
In Artificial Life XI: Proceedings of the Eleventh International Conference on the Simulation and Synthesis of Living Systems.
MIT Press.
.
Record type:
Conference or Workshop Item
(Paper)
Abstract
Kauffman’s seminal NK model was introduced to relate the properties of fitness landscapes to the extent and nature of epistasis between genes. The original model considered genomes in which the fitness contribution of each of N genes was influenced by the value of K other genes located either at random or from the immediately neighbouring loci on the genome. Both schemes ensure that (on average) every gene is as influential as any other. More recently, the epistatic connectivity between genes in natural genomes has begun to be mapped. The topologies of these genetic networks are neither random nor regular, but exhibit interesting structural properties. The model presented here extends the NK model to consider epistatic network topologies derived from a preferential attachment scheme which tends to ensure that some genes are more influential than others. We explore the consequences of this topology for the properties of the associated fitness landscapes.
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NKalpha_non-uniform_epistatic_interactions_in_an_extended_NK_model.pdf
- Accepted Manuscript
Text
ALIFExi_pp234-241.pdf
- Version of Record
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Published date: 20 May 2008
Organisations:
Agents, Interactions & Complexity
Identifiers
Local EPrints ID: 265781
URI: http://eprints.soton.ac.uk/id/eprint/265781
PURE UUID: c52dffa5-97bc-4c25-8af4-c4653689c13d
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Date deposited: 22 May 2008 15:32
Last modified: 09 Apr 2024 09:58
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Contributors
Author:
Tom Hebbron
Author:
Dave Cliff
Editor:
Seth Bullock
Editor:
Jason Noble
Editor:
Richard Watson
Editor:
Mark A. Bedau
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