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NKalpha: Non-uniform epistatic interactions in an extended NK model

NKalpha: Non-uniform epistatic interactions in an extended NK model
NKalpha: Non-uniform epistatic interactions in an extended NK model
Kauffman’s seminal NK model was introduced to relate the properties of fitness landscapes to the extent and nature of epistasis between genes. The original model considered genomes in which the fitness contribution of each of N genes was influenced by the value of K other genes located either at random or from the immediately neighbouring loci on the genome. Both schemes ensure that (on average) every gene is as influential as any other. More recently, the epistatic connectivity between genes in natural genomes has begun to be mapped. The topologies of these genetic networks are neither random nor regular, but exhibit interesting structural properties. The model presented here extends the NK model to consider epistatic network topologies derived from a preferential attachment scheme which tends to ensure that some genes are more influential than others. We explore the consequences of this topology for the properties of the associated fitness landscapes.
234-241
MIT Press, Cambridge, MA
Hebbron, Tom
24aac6f9-0241-48be-a3d8-8468319dc46a
Bullock, Seth
2ad576e4-56b8-4f31-84e0-51bd0b7a1cd3
Cliff, Dave
693f4867-967f-426b-8551-b60c8494ee62
Bullock, Seth
Noble, Jason
Watson, Richard
Bedau, Mark A.
Hebbron, Tom
24aac6f9-0241-48be-a3d8-8468319dc46a
Bullock, Seth
2ad576e4-56b8-4f31-84e0-51bd0b7a1cd3
Cliff, Dave
693f4867-967f-426b-8551-b60c8494ee62
Bullock, Seth
Noble, Jason
Watson, Richard
Bedau, Mark A.

Hebbron, Tom, Bullock, Seth and Cliff, Dave (2008) NKalpha: Non-uniform epistatic interactions in an extended NK model. Bullock, Seth, Noble, Jason, Watson, Richard and Bedau, Mark A. (eds.) In Artificial Life XI: Proceedings of the Eleventh International Conference on the Simulation and Synthesis of Living Systems. MIT Press, Cambridge, MA. pp. 234-241 .

Record type: Conference or Workshop Item (Paper)

Abstract

Kauffman’s seminal NK model was introduced to relate the properties of fitness landscapes to the extent and nature of epistasis between genes. The original model considered genomes in which the fitness contribution of each of N genes was influenced by the value of K other genes located either at random or from the immediately neighbouring loci on the genome. Both schemes ensure that (on average) every gene is as influential as any other. More recently, the epistatic connectivity between genes in natural genomes has begun to be mapped. The topologies of these genetic networks are neither random nor regular, but exhibit interesting structural properties. The model presented here extends the NK model to consider epistatic network topologies derived from a preferential attachment scheme which tends to ensure that some genes are more influential than others. We explore the consequences of this topology for the properties of the associated fitness landscapes.

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Published date: 20 May 2008
Organisations: Agents, Interactions & Complexity

Identifiers

Local EPrints ID: 265781
URI: http://eprints.soton.ac.uk/id/eprint/265781
PURE UUID: c52dffa5-97bc-4c25-8af4-c4653689c13d

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Date deposited: 22 May 2008 15:32
Last modified: 25 Jun 2020 16:46

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