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Typical Waldenstrom macroglobulinemia is derived from a B-cell arrested after cessation of somatic mutation but prior to isotype switch events

Typical Waldenstrom macroglobulinemia is derived from a B-cell arrested after cessation of somatic mutation but prior to isotype switch events
Typical Waldenstrom macroglobulinemia is derived from a B-cell arrested after cessation of somatic mutation but prior to isotype switch events
There exists a wide spectrum of IgM-secreting B-cell tumors with different clinical behavior. Knowledge of the VH gene status can reveal their origin and clonal history. For Waldenstrom macroglobulinemia (WM), a distinct subtype of lymphoplasmacytic lymphoma, early data on limited sequences showed evidence for somatic mutation. A recent report of one case demonstrated intraclonal mutational activity occurring after transformation, a characteristic of germinal center lymphomas. To extend the investigation, we have analyzed 7 cases of WM. VH genes were somatically mutated with no evidence of intraclonal variation in all cases. In contrast to IgM-secreting multiple myeloma, there was no evidence for isotype switch transcripts in any of the cases. These data support the concept that typical WM is derived from a B cell that has undergone somatic mutation prior to transformation, at a point where isotype switch events have not been initiated.
0006-4971
1505-1507
Sahota, Surinder S.
66c1457f-cba2-4c49-9c8c-fcee0748b6b8
Forconi, Francesco
ce9ed873-58cf-4876-bf3a-9ba1d163edc8
Ottensmeier, Christian H.
42b8a398-baac-4843-a3d6-056225675797
Provan, Drew
25396fb0-33ad-4c0d-b66f-082825030930
Oscier, David G.
c2620a1d-25bb-48f7-9651-f5d023636381
Hamblin, Terry J.
57389613-7900-48fd-b3e6-8ca8fbdceccb
Stevenson, Freda K.
ba803747-c0ac-409f-a9c2-b61fde009f8c
Sahota, Surinder S.
66c1457f-cba2-4c49-9c8c-fcee0748b6b8
Forconi, Francesco
ce9ed873-58cf-4876-bf3a-9ba1d163edc8
Ottensmeier, Christian H.
42b8a398-baac-4843-a3d6-056225675797
Provan, Drew
25396fb0-33ad-4c0d-b66f-082825030930
Oscier, David G.
c2620a1d-25bb-48f7-9651-f5d023636381
Hamblin, Terry J.
57389613-7900-48fd-b3e6-8ca8fbdceccb
Stevenson, Freda K.
ba803747-c0ac-409f-a9c2-b61fde009f8c

Sahota, Surinder S., Forconi, Francesco, Ottensmeier, Christian H., Provan, Drew, Oscier, David G., Hamblin, Terry J. and Stevenson, Freda K. (2002) Typical Waldenstrom macroglobulinemia is derived from a B-cell arrested after cessation of somatic mutation but prior to isotype switch events. Blood, 100 (4), 1505-1507.

Record type: Article

Abstract

There exists a wide spectrum of IgM-secreting B-cell tumors with different clinical behavior. Knowledge of the VH gene status can reveal their origin and clonal history. For Waldenstrom macroglobulinemia (WM), a distinct subtype of lymphoplasmacytic lymphoma, early data on limited sequences showed evidence for somatic mutation. A recent report of one case demonstrated intraclonal mutational activity occurring after transformation, a characteristic of germinal center lymphomas. To extend the investigation, we have analyzed 7 cases of WM. VH genes were somatically mutated with no evidence of intraclonal variation in all cases. In contrast to IgM-secreting multiple myeloma, there was no evidence for isotype switch transcripts in any of the cases. These data support the concept that typical WM is derived from a B cell that has undergone somatic mutation prior to transformation, at a point where isotype switch events have not been initiated.

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Published date: 15 August 2002

Identifiers

Local EPrints ID: 26585
URI: http://eprints.soton.ac.uk/id/eprint/26585
ISSN: 0006-4971
PURE UUID: 3ea0182c-37e9-40b9-80ce-627894ab30af
ORCID for Freda K. Stevenson: ORCID iD orcid.org/0000-0002-0933-5021

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Date deposited: 20 Apr 2006
Last modified: 17 Dec 2019 01:57

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