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Population-based demographic study of karyotypes in 1709 patients with adult Acute Myeloid Leukemia

Population-based demographic study of karyotypes in 1709 patients with adult Acute Myeloid Leukemia
Population-based demographic study of karyotypes in 1709 patients with adult Acute Myeloid Leukemia
Few large demographic studies of acute myeloid leukemia (AML) are derived from population-based registries. Demographic and karyotypic data were provided for AML cases from two regional leukemia registry databases in Scotland and the Northern Region of England. A population-based dataset was compiled, comprising 1709 patients aged >16 years (1235 North England/474 Scotland patients). The most common cytogenetic abnormalities involved chromosomes 5 and/or 7 (17%). Patients with the following abnormal chromosome 5/7 combinations: -5, del(5q), -5/-7 and del(5q)/-7 represented a significantly older population (P<0.01, ANOVA). t(8;21) was the only 'favourable' karyotype found in older age. Karyotypic complexity varied within chromosome 5/7 combination groups; those containing -5, -5/-7, -5/del(7q), del(5q)/-7 or del(5q)/del(7q) combinations were significantly more frequently complex than those containing -7 and del(7q) (P<0.01, 2 test). Additional recurring cytogenetic abnormalities within complex karyotypes containing chromosome 5/7 combinations included (in order of frequency), abnormalities of chromosomes 17, 12, 3 and 18. Complex karyotypes not involving chromosomes 5 or 7 represented 30% of all complex karyotypes, occurred in younger patients than those involving chromosomes 5 and 7, and frequently included additional trisomy 8 (26%). In conclusion, we describe subgroups within adverse karyotypes, with different demographics, degree of complexity and additional chromosome abnormalities.
0887-6924
444-450
Sanderson, R.N.
5a43edde-8383-402f-b3cc-f963ba3673a2
Johnson, P.R.
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Moorman, A.V.
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Roman, E.
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Willett, E.
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Taylor, P.R.
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Proctor, S.J.
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Bown, N.
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Ogston, S.
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Bowen, D.T.
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Sanderson, R.N.
5a43edde-8383-402f-b3cc-f963ba3673a2
Johnson, P.R.
3f6068ce-171e-4c2c-aca9-dc9b6a37413f
Moorman, A.V.
af5027f3-4927-4e62-b1be-ac4bdcf6cd8f
Roman, E.
5f184e94-d01d-40b5-8cbe-6dd6335a850b
Willett, E.
cb495e58-45b5-49c4-8fa6-c7cd378b2d20
Taylor, P.R.
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Proctor, S.J.
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Bown, N.
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Ogston, S.
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Bowen, D.T.
676c2629-037d-4ca2-ab7d-93a020a8a3d5

Sanderson, R.N., Johnson, P.R., Moorman, A.V., Roman, E., Willett, E., Taylor, P.R., Proctor, S.J., Bown, N., Ogston, S. and Bowen, D.T. (2006) Population-based demographic study of karyotypes in 1709 patients with adult Acute Myeloid Leukemia. Leukemia, 20 (3), 444-450. (doi:10.1038/sj.leu.2404055).

Record type: Article

Abstract

Few large demographic studies of acute myeloid leukemia (AML) are derived from population-based registries. Demographic and karyotypic data were provided for AML cases from two regional leukemia registry databases in Scotland and the Northern Region of England. A population-based dataset was compiled, comprising 1709 patients aged >16 years (1235 North England/474 Scotland patients). The most common cytogenetic abnormalities involved chromosomes 5 and/or 7 (17%). Patients with the following abnormal chromosome 5/7 combinations: -5, del(5q), -5/-7 and del(5q)/-7 represented a significantly older population (P<0.01, ANOVA). t(8;21) was the only 'favourable' karyotype found in older age. Karyotypic complexity varied within chromosome 5/7 combination groups; those containing -5, -5/-7, -5/del(7q), del(5q)/-7 or del(5q)/del(7q) combinations were significantly more frequently complex than those containing -7 and del(7q) (P<0.01, 2 test). Additional recurring cytogenetic abnormalities within complex karyotypes containing chromosome 5/7 combinations included (in order of frequency), abnormalities of chromosomes 17, 12, 3 and 18. Complex karyotypes not involving chromosomes 5 or 7 represented 30% of all complex karyotypes, occurred in younger patients than those involving chromosomes 5 and 7, and frequently included additional trisomy 8 (26%). In conclusion, we describe subgroups within adverse karyotypes, with different demographics, degree of complexity and additional chromosome abnormalities.

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Published date: 2006

Identifiers

Local EPrints ID: 26591
URI: http://eprints.soton.ac.uk/id/eprint/26591
ISSN: 0887-6924
PURE UUID: b392ec2a-b95e-4b6a-b303-5023c3991ea8
ORCID for P.R. Johnson: ORCID iD orcid.org/0000-0003-2306-4974

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Date deposited: 12 Apr 2006
Last modified: 17 Dec 2019 01:55

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Contributors

Author: R.N. Sanderson
Author: P.R. Johnson ORCID iD
Author: A.V. Moorman
Author: E. Roman
Author: E. Willett
Author: P.R. Taylor
Author: S.J. Proctor
Author: N. Bown
Author: S. Ogston
Author: D.T. Bowen

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