BAG-1: a multi-functional pro-survival molecule
BAG-1: a multi-functional pro-survival molecule
BAG-1 is a multi-functional protein that exists as three functionally distinct and differentially localized isoforms which originate from a single mRNA and interact with a wide range of cellular targets. These include heat shock proteins, nuclear hormone receptors, signalling molecules, the anti-apoptotic BCL-2 protein and components of the ubiquitylation/proteasome machinery. Overexpression of BAG-1 isoforms has been demonstrated to regulate apoptosis, proliferation, transcription, metastasis and cell motility in a wide variety of cell systems. Since BAG-1 has a role in many biological pathways there is increasing evidence supporting the view that BAG-1 is an important molecule in disease, for example, potentially modulating both cell survival and response to nuclear hormones in breast cancer, and BAG-1 is a potential molecular target for therapeutic intervention.
BAG-1, apoptosis, cancer, HSC70, HSP70, ubiquitin, proteasome
251-259
Townsend, Paul A.
a2680443-664e-46d0-b4dd-97456ba810db
Stephanou, Anastasis
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Packham, Graham
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Latchman, David S.
71e9db7c-9075-4b49-afac-6413085378db
2005
Townsend, Paul A.
a2680443-664e-46d0-b4dd-97456ba810db
Stephanou, Anastasis
e9d502e8-693c-4458-a3c6-5e2844665db3
Packham, Graham
fdabe56f-2c58-469c-aadf-38878f233394
Latchman, David S.
71e9db7c-9075-4b49-afac-6413085378db
Townsend, Paul A., Stephanou, Anastasis, Packham, Graham and Latchman, David S.
(2005)
BAG-1: a multi-functional pro-survival molecule.
International Journal of Biochemistry & Cell Biology, 37 (2), .
(doi:10.1016/j.biocel.2004.03.016).
Abstract
BAG-1 is a multi-functional protein that exists as three functionally distinct and differentially localized isoforms which originate from a single mRNA and interact with a wide range of cellular targets. These include heat shock proteins, nuclear hormone receptors, signalling molecules, the anti-apoptotic BCL-2 protein and components of the ubiquitylation/proteasome machinery. Overexpression of BAG-1 isoforms has been demonstrated to regulate apoptosis, proliferation, transcription, metastasis and cell motility in a wide variety of cell systems. Since BAG-1 has a role in many biological pathways there is increasing evidence supporting the view that BAG-1 is an important molecule in disease, for example, potentially modulating both cell survival and response to nuclear hormones in breast cancer, and BAG-1 is a potential molecular target for therapeutic intervention.
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Published date: 2005
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Molecules in Focus
Keywords:
BAG-1, apoptosis, cancer, HSC70, HSP70, ubiquitin, proteasome
Identifiers
Local EPrints ID: 26645
URI: http://eprints.soton.ac.uk/id/eprint/26645
ISSN: 1357-2725
PURE UUID: 5717d9f8-d439-42fa-b6df-6c5f80ee0341
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Date deposited: 10 Apr 2006
Last modified: 16 Mar 2024 03:14
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Author:
Paul A. Townsend
Author:
Anastasis Stephanou
Author:
David S. Latchman
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