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Dielectrophoretic Manipulation and Characterisation of Herpes SimplexVirus-1 Capsids

Dielectrophoretic Manipulation and Characterisation of Herpes SimplexVirus-1 Capsids
Dielectrophoretic Manipulation and Characterisation of Herpes SimplexVirus-1 Capsids
The dielectrophoretic behaviour of the capsids of herpes simplex virus type-1 has been measured over a range of conductivities of KCl solutions, with and without the addition of mannitol. The dielectrophoretic response of the capsids was recorded by measuring the frequency corresponding to zero dielectrophoretic force. The data were analysed using a multi-shelled model, and the permittivity and conductivity of the particles estimated. The capsid was modelled as a porous protein shell through which suspending medium passes, an inner chamber containing suspending medium in equilibrium with the outside, and a central core of protein (the scaffold). Capsids suspended in KCl without mannitol exhibited a different behaviour to those suspended in KCl with mannitol.
0175-7571
268-272
Hughes, M.P
c391599b-33ee-41c0-9e7f-479f0d2c7971
Morgan, Hywel
de00d59f-a5a2-48c4-a99a-1d5dd7854174
Rixon, F.J
be556a7a-0f91-4341-8ddf-2c4e7cc764ad
Hughes, M.P
c391599b-33ee-41c0-9e7f-479f0d2c7971
Morgan, Hywel
de00d59f-a5a2-48c4-a99a-1d5dd7854174
Rixon, F.J
be556a7a-0f91-4341-8ddf-2c4e7cc764ad

Hughes, M.P, Morgan, Hywel and Rixon, F.J (2001) Dielectrophoretic Manipulation and Characterisation of Herpes SimplexVirus-1 Capsids. European Biophysics Journal, 30 (4), 268-272.

Record type: Article

Abstract

The dielectrophoretic behaviour of the capsids of herpes simplex virus type-1 has been measured over a range of conductivities of KCl solutions, with and without the addition of mannitol. The dielectrophoretic response of the capsids was recorded by measuring the frequency corresponding to zero dielectrophoretic force. The data were analysed using a multi-shelled model, and the permittivity and conductivity of the particles estimated. The capsid was modelled as a porous protein shell through which suspending medium passes, an inner chamber containing suspending medium in equilibrium with the outside, and a central core of protein (the scaffold). Capsids suspended in KCl without mannitol exhibited a different behaviour to those suspended in KCl with mannitol.

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More information

Published date: August 2001
Organisations: Nanoelectronics and Nanotechnology

Identifiers

Local EPrints ID: 266496
URI: https://eprints.soton.ac.uk/id/eprint/266496
ISSN: 0175-7571
PURE UUID: 82b41081-1b7f-407d-a0b1-0213f3d17ee1
ORCID for Hywel Morgan: ORCID iD orcid.org/0000-0003-4850-5676

Catalogue record

Date deposited: 03 Aug 2008 23:53
Last modified: 06 Jun 2018 12:45

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