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Measurements of the properties of Herpes Simplex Virus Type 1 virions with dielectrophoresis.

Hughes, M.P, Morgan, Hywel and Rixon, F.P (2002) Measurements of the properties of Herpes Simplex Virus Type 1 virions with dielectrophoresis. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1571, (1), pp. 1-8.

Record type: Article


An investigation has been performed into the biophysical properties of the enveloped mammalian virus, herpes simplex virus type 1 (HSV-1). The dielectrophoretic behaviour of the virus particles was measured as a function of applied frequency (over the range 100 kHz–20 MHz) and conductivity of the suspending medium (over the range 1–100 mS m?1). The dielectric properties of the virus were determined from the dielectrophoretic data using the smeared-out shell model. The data suggest that the intact particle has a surface conductance of 0.3 nS, an internal and membrane permittivity of 75var epsilono and 7.5var epsilono, respectively, an internal conductivity of approximately 0.1 S m?1 and a zeta potential of 70 mV. The dielectric properties were measured for intact, fresh virus particles and also for particles following exposure to various modifying agents, such as treatment with enzymes, ionophores and ageing. It is shown that the observed changes in the dielectrophoretic spectrum, and the variations in the dielectric properties of the virus concur with the expected physiological effects of these agents.

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Published date: May 2002
Organisations: Nanoelectronics and Nanotechnology


Local EPrints ID: 266498
ISSN: 0304-4165
PURE UUID: e79b4b2c-c3f7-4cb1-b7d9-fefe21a9292e
ORCID for Hywel Morgan: ORCID iD

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Date deposited: 04 Aug 2008 00:36
Last modified: 01 Oct 2017 03:20

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Author: M.P Hughes
Author: Hywel Morgan ORCID iD
Author: F.P Rixon

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