The University of Southampton
University of Southampton Institutional Repository

The cell biology of MHC class I antigen presentation

Record type: Article

MHC class I antigen presentation refers to the co-ordinated activities of many intracellular pathways that promote the cell surface appearance of MHC class I/?2m heterodimers loaded with a spectrum of self or foreign peptides. These MHC class I peptide complexes form ligands for CD8 positive T cells and NK cells. MHC class I heterodimers are loaded within the endoplasmic reticulum (ER) with peptides derived from intracellular proteins. Alternatively, MHC class I molecules may be loaded with peptides derived from extracellular proteins in a process called MHC class I cross presentation. This pathway is less well defined but can overlap those pathways operating in classical MHC class I presentation and has recently been reviewed elsewhere (1). This review will address the current concepts regarding the intracellular assembly of MHC class I molecules with their peptide cargo within the ER and their subsequent progress to the cell surface.

Full text not available from this repository.

Citation

Williams, A., Peh, C.A. and Elliott, T. (2002) The cell biology of MHC class I antigen presentation Tissue Antigens, 59, (1), pp. 3-17. (doi:10.1034/j.1399-0039.2002.590103.x).

More information

Published date: 2002

Identifiers

Local EPrints ID: 26662
URI: http://eprints.soton.ac.uk/id/eprint/26662
ISSN: 0001-2815
PURE UUID: 803f30e9-6494-47bd-a4b7-c4b1584238d3
ORCID for T. Elliott: ORCID iD orcid.org/0000-0003-1097-0222

Catalogue record

Date deposited: 21 Apr 2006
Last modified: 17 Jul 2017 16:06

Export record

Altmetrics

Contributors

Author: A. Williams
Author: C.A. Peh
Author: T. Elliott ORCID iD

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×