The cell biology of MHC class I antigen presentation

Williams, A., Peh, C.A. and Elliott, T. (2002) The cell biology of MHC class I antigen presentation Tissue Antigens, 59, (1), pp. 3-17. (doi:10.1034/j.1399-0039.2002.590103.x).


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MHC class I antigen presentation refers to the co-ordinated activities of many intracellular pathways that promote the cell surface appearance of MHC class I/?2m heterodimers loaded with a spectrum of self or foreign peptides. These MHC class I peptide complexes form ligands for CD8 positive T cells and NK cells. MHC class I heterodimers are loaded within the endoplasmic reticulum (ER) with peptides derived from intracellular proteins. Alternatively, MHC class I molecules may be loaded with peptides derived from extracellular proteins in a process called MHC class I cross presentation. This pathway is less well defined but can overlap those pathways operating in classical MHC class I presentation and has recently been reviewed elsewhere (1). This review will address the current concepts regarding the intracellular assembly of MHC class I molecules with their peptide cargo within the ER and their subsequent progress to the cell surface.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1034/j.1399-0039.2002.590103.x
ISSNs: 0001-2815 (print)
Related URLs:
Subjects: R Medicine > R Medicine (General)
ePrint ID: 26662
Date :
Date Event
Date Deposited: 21 Apr 2006
Last Modified: 16 Apr 2017 22:32
Further Information:Google Scholar

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