Optimization of the MHC class I peptide cargo is dependent on tapasin


Williams, Anthony P., Peh, Chen Au, Purcell, Anthony W., McCluskey, James and Elliott, Tim (2002) Optimization of the MHC class I peptide cargo is dependent on tapasin Immunity, 16, (4), pp. 509-520. (doi:10.1016/S1074-7613(02)00304-7).

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Description/Abstract

The loading of MHC class I molecules with their peptide cargo is undertaken by a multimolecular peptide loading complex within the endoplasmic reticulum. We show that MHC class I molecules can optimize their peptide repertoire over time and that this process is dependent on tapasin. Optimization of the peptide repertoire is both quantitatively and qualitatively improved by tapasin. The extent of optimization is maximal when MHC class I molecules are allowed to load within the fully assembled peptide loading complex. Finally, we identify a single natural polymorphism (116D>Y) in HLA-B*4402 that permits tapasin-independent loading of HLA-B*4405 (116Y). In the presence of tapasin, the tapasin-independent allele B*4405 (116Y) acquires a repertoire of peptides that is less optimal than the tapasin-dependent allele B*4402 (116D).

Item Type: Article
Digital Object Identifier (DOI): doi:10.1016/S1074-7613(02)00304-7
ISSNs: 1097-4180 (print)
Related URLs:
Subjects: Q Science > QR Microbiology > QR180 Immunology
ePrint ID: 26663
Date :
Date Event
April 2002Published
Date Deposited: 21 Apr 2006
Last Modified: 16 Apr 2017 22:32
Further Information:Google Scholar
URI: http://eprints.soton.ac.uk/id/eprint/26663

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