DNA fusion vaccines against B-cell tumors
DNA fusion vaccines against B-cell tumors
DNA vaccination is currently being explored as a potential strategy for combatting cancer. However, tumor antigens are often weak and the immune system of patients may be compromised. For B-cell tumors, immunoglobulin idiotypic antigens provide defined targets but are poorly immunogenic. Fusion of a sequence derived from tetanus toxin to the genes encoding idiotypic determinants has proved highly effective in activating protective anti-tumor immunity. DNA fusion vaccines containing immuno-enhancing sequences can augment and direct immune attack on a range of target antigens. Gene-based fusion vaccines offer ease of manipulation and flexible design to activate effective attack on cancer.
DNA vaccine, tetanus toxin, fusion vaccine, B-cell tumor, lymphoma, myeloma
566-572
Zhu, Delin
49eeb78f-f607-4079-80b3-45574dc41fa5
Rice, Jason
d58d4fcd-8dc0-4599-bf96-62323d579227
Savelyeva, Natalia
804c3e15-d260-4717-9b7c-15c16ba87fc7
Stevenson, Freda K.
ba803747-c0ac-409f-a9c2-b61fde009f8c
2001
Zhu, Delin
49eeb78f-f607-4079-80b3-45574dc41fa5
Rice, Jason
d58d4fcd-8dc0-4599-bf96-62323d579227
Savelyeva, Natalia
804c3e15-d260-4717-9b7c-15c16ba87fc7
Stevenson, Freda K.
ba803747-c0ac-409f-a9c2-b61fde009f8c
Zhu, Delin, Rice, Jason, Savelyeva, Natalia and Stevenson, Freda K.
(2001)
DNA fusion vaccines against B-cell tumors.
Trends in Molecular Medicine, 7 (12), .
(doi:10.1016/S1471-4914(01)02126-8).
Abstract
DNA vaccination is currently being explored as a potential strategy for combatting cancer. However, tumor antigens are often weak and the immune system of patients may be compromised. For B-cell tumors, immunoglobulin idiotypic antigens provide defined targets but are poorly immunogenic. Fusion of a sequence derived from tetanus toxin to the genes encoding idiotypic determinants has proved highly effective in activating protective anti-tumor immunity. DNA fusion vaccines containing immuno-enhancing sequences can augment and direct immune attack on a range of target antigens. Gene-based fusion vaccines offer ease of manipulation and flexible design to activate effective attack on cancer.
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Published date: 2001
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Review Article
Keywords:
DNA vaccine, tetanus toxin, fusion vaccine, B-cell tumor, lymphoma, myeloma
Identifiers
Local EPrints ID: 26675
URI: http://eprints.soton.ac.uk/id/eprint/26675
ISSN: 1471-4914
PURE UUID: 1087f13d-4ffb-4dd6-9357-046165a64e35
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Date deposited: 24 Apr 2006
Last modified: 16 Mar 2024 02:54
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Author:
Delin Zhu
Author:
Jason Rice
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