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DNA fusion vaccines against B-cell tumors

Zhu, Delin, Rice, Jason, Savelyeva, Natalia and Stevenson, Freda K. (2001) DNA fusion vaccines against B-cell tumors Trends in Molecular Medicine, 7, (12), pp. 566-572. (doi:10.1016/S1471-4914(01)02126-8).

Record type: Article

Abstract

DNA vaccination is currently being explored as a potential strategy for combatting cancer. However, tumor antigens are often weak and the immune system of patients may be compromised. For B-cell tumors, immunoglobulin idiotypic antigens provide defined targets but are poorly immunogenic. Fusion of a sequence derived from tetanus toxin to the genes encoding idiotypic determinants has proved highly effective in activating protective anti-tumor immunity. DNA fusion vaccines containing immuno-enhancing sequences can augment and direct immune attack on a range of target antigens. Gene-based fusion vaccines offer ease of manipulation and flexible design to activate effective attack on cancer.

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More information

Published date: 2001
Additional Information: Review Article
Keywords: DNA vaccine, tetanus toxin, fusion vaccine, B-cell tumor, lymphoma, myeloma

Identifiers

Local EPrints ID: 26675
URI: http://eprints.soton.ac.uk/id/eprint/26675
ISSN: 1471-4914
PURE UUID: 1087f13d-4ffb-4dd6-9357-046165a64e35

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Date deposited: 24 Apr 2006
Last modified: 17 Jul 2017 16:06

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Contributors

Author: Delin Zhu
Author: Jason Rice

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