The University of Southampton
University of Southampton Institutional Repository

V(H) gene analysis of splenic marginal zone lymphomas reveals diversity in mutational status and initiation of somatic mutation in vivo

V(H) gene analysis of splenic marginal zone lymphomas reveals diversity in mutational status and initiation of somatic mutation in vivo
V(H) gene analysis of splenic marginal zone lymphomas reveals diversity in mutational status and initiation of somatic mutation in vivo
Tumors of the splenic marginal zone can present in spleen or blood. The maturational status of the neoplastic B cells from each site appears heterogeneous, with either unmutated or mutated variable-region heavy chain (VH) genes. To determine an influence of tissue location, we assessed matched blood and splenic tumor cells from 4 patients and found them identical. However, one patient with unmutated VH genes in blood and spleen developed a clonally related diffuse large B-cell lymphoma in the chest wall. Strikingly, this subclone had undergone significant somatic mutation, with clear intraclonal heterogeneity. To our knowledge, this is the first case of a B-cell tumor showing initiation of somatic mutation in vivo. The finding emphasizes that the tissue microenvironment can influence tumor cell behavior and possibly affect disease progression. Importantly, because several replacement mutations were located within or close to the complementarity-determining regions (CDRs), it raises the question of a role for antigen in driving tumor growth.
0006-4971
2659-2661
Zhu, Delin
49eeb78f-f607-4079-80b3-45574dc41fa5
Orchard, Jennifer
0e19209b-25ba-494b-b33e-61ce6fb12e27
Oscier, David G.
c2620a1d-25bb-48f7-9651-f5d023636381
Wright, Dennis H.
791e0346-8ff3-4d45-936f-665ca2e8b44c
Stevenson, Freda K.
ba803747-c0ac-409f-a9c2-b61fde009f8c
Zhu, Delin
49eeb78f-f607-4079-80b3-45574dc41fa5
Orchard, Jennifer
0e19209b-25ba-494b-b33e-61ce6fb12e27
Oscier, David G.
c2620a1d-25bb-48f7-9651-f5d023636381
Wright, Dennis H.
791e0346-8ff3-4d45-936f-665ca2e8b44c
Stevenson, Freda K.
ba803747-c0ac-409f-a9c2-b61fde009f8c

Zhu, Delin, Orchard, Jennifer, Oscier, David G., Wright, Dennis H. and Stevenson, Freda K. (2002) V(H) gene analysis of splenic marginal zone lymphomas reveals diversity in mutational status and initiation of somatic mutation in vivo. Blood, 100 (7), 2659-2661. (doi:10.1182/blood-2002-01-0169).

Record type: Article

Abstract

Tumors of the splenic marginal zone can present in spleen or blood. The maturational status of the neoplastic B cells from each site appears heterogeneous, with either unmutated or mutated variable-region heavy chain (VH) genes. To determine an influence of tissue location, we assessed matched blood and splenic tumor cells from 4 patients and found them identical. However, one patient with unmutated VH genes in blood and spleen developed a clonally related diffuse large B-cell lymphoma in the chest wall. Strikingly, this subclone had undergone significant somatic mutation, with clear intraclonal heterogeneity. To our knowledge, this is the first case of a B-cell tumor showing initiation of somatic mutation in vivo. The finding emphasizes that the tissue microenvironment can influence tumor cell behavior and possibly affect disease progression. Importantly, because several replacement mutations were located within or close to the complementarity-determining regions (CDRs), it raises the question of a role for antigen in driving tumor growth.

Full text not available from this repository.

More information

Published date: 2002

Identifiers

Local EPrints ID: 26676
URI: http://eprints.soton.ac.uk/id/eprint/26676
ISSN: 0006-4971
PURE UUID: 0e80de9d-9a1f-4935-86d1-03eef02618a9
ORCID for Freda K. Stevenson: ORCID iD orcid.org/0000-0002-0933-5021

Catalogue record

Date deposited: 24 Apr 2006
Last modified: 17 Dec 2019 01:57

Export record

Altmetrics

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×