DNA gene fusion vaccines against cancer
DNA gene fusion vaccines against cancer
The ability of DNA vaccination to induce effective immune responses has been shown in a range of preclinical disease models. However, the potency of DNA vaccines must be further improved for their use in patients. DNA fusion vaccine strategies, whereby target antigens are genetically linked to immuno-enhancing molecules, are currently being explored. The ease of DNA manipulation has allowed incorporation of a wide variety of molecules able to promote antigen uptake, processing and presentation by professional antigen-presenting cells, to provide critical CD4 T-cell help and to activate more effective immune effector pathways. These strategies are particularly important for cancer vaccines to increase their immunogenicity and to overcome tolerance.
41-48
Zhu, D.
4f4f12ef-d220-4a7b-a1a0-63c6b66b9e17
Stevenson, F.K.
ba803747-c0ac-409f-a9c2-b61fde009f8c
2002
Zhu, D.
4f4f12ef-d220-4a7b-a1a0-63c6b66b9e17
Stevenson, F.K.
ba803747-c0ac-409f-a9c2-b61fde009f8c
Zhu, D. and Stevenson, F.K.
(2002)
DNA gene fusion vaccines against cancer.
Current Opinion in Molecular Therapeutics, 4 (1), .
Abstract
The ability of DNA vaccination to induce effective immune responses has been shown in a range of preclinical disease models. However, the potency of DNA vaccines must be further improved for their use in patients. DNA fusion vaccine strategies, whereby target antigens are genetically linked to immuno-enhancing molecules, are currently being explored. The ease of DNA manipulation has allowed incorporation of a wide variety of molecules able to promote antigen uptake, processing and presentation by professional antigen-presenting cells, to provide critical CD4 T-cell help and to activate more effective immune effector pathways. These strategies are particularly important for cancer vaccines to increase their immunogenicity and to overcome tolerance.
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Published date: 2002
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Local EPrints ID: 26678
URI: http://eprints.soton.ac.uk/id/eprint/26678
ISSN: 1464-8431
PURE UUID: 749d6d37-5025-45db-875c-6784902cc79b
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Date deposited: 24 Apr 2006
Last modified: 23 Jul 2022 01:41
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Author:
D. Zhu
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