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Monitoring kinetics in the artificial human asthmatic airway using electrical impedance spectroscopy

Monitoring kinetics in the artificial human asthmatic airway using electrical impedance spectroscopy
Monitoring kinetics in the artificial human asthmatic airway using electrical impedance spectroscopy
Asthma is an herited disorder, but the remarkable increases in prevalence worldwide over the last three generations can not be directly attributed to genetic susceptibility since there has been insufficient time for gene frequency changes to occur. Recognizing that asthma has an underlying genetic predisposition, human disease tissue-based in vitro models of asthma have been developed, focusing on the airway epithelium. However, these models are relatively simplistic, low throughout systems and are limited, not only by the availability of tissue, but also by the paucity of non-destructive and non-invasive tools to continuously monitor the behavior of the cells. Electrical impedance spectroscopy (EIS) is a non-invasive and label-free technique that can be used to probe and monitor the properties of cells, and has been recently developed for high speed single cell analysis. In this paper we describe an impedance-based cell sensing chip that is used to monitor the kinetics of tight junctions in the human bronchial epithelial cell monolayer.
Sun, Tao
b2f8e932-a7e6-4fe7-94dd-5c4ce725eacb
Molnar, Camelia
39b09914-aaf1-4997-b032-4dee91060d40
Davies, Donna
70a12c43-7af8-4902-90c6-105fc4c1849e
Morgan, Hywel
de00d59f-a5a2-48c4-a99a-1d5dd7854174
Sun, Tao
b2f8e932-a7e6-4fe7-94dd-5c4ce725eacb
Molnar, Camelia
39b09914-aaf1-4997-b032-4dee91060d40
Davies, Donna
70a12c43-7af8-4902-90c6-105fc4c1849e
Morgan, Hywel
de00d59f-a5a2-48c4-a99a-1d5dd7854174

Sun, Tao, Molnar, Camelia, Davies, Donna and Morgan, Hywel (2008) Monitoring kinetics in the artificial human asthmatic airway using electrical impedance spectroscopy. 12th annual European conference on micro & nanoscale technologies for biosciences, Switzerland. 16 - 19 Nov 2008.

Record type: Conference or Workshop Item (Poster)

Abstract

Asthma is an herited disorder, but the remarkable increases in prevalence worldwide over the last three generations can not be directly attributed to genetic susceptibility since there has been insufficient time for gene frequency changes to occur. Recognizing that asthma has an underlying genetic predisposition, human disease tissue-based in vitro models of asthma have been developed, focusing on the airway epithelium. However, these models are relatively simplistic, low throughout systems and are limited, not only by the availability of tissue, but also by the paucity of non-destructive and non-invasive tools to continuously monitor the behavior of the cells. Electrical impedance spectroscopy (EIS) is a non-invasive and label-free technique that can be used to probe and monitor the properties of cells, and has been recently developed for high speed single cell analysis. In this paper we describe an impedance-based cell sensing chip that is used to monitor the kinetics of tight junctions in the human bronchial epithelial cell monolayer.

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More information

Published date: November 2008
Additional Information: Event Dates: 16th -19th, November, 2008
Venue - Dates: 12th annual European conference on micro & nanoscale technologies for biosciences, Switzerland, 2008-11-16 - 2008-11-19
Organisations: Nanoelectronics and Nanotechnology

Identifiers

Local EPrints ID: 266905
URI: https://eprints.soton.ac.uk/id/eprint/266905
PURE UUID: d10d3448-ad33-41f2-8df4-7d60ee193560
ORCID for Hywel Morgan: ORCID iD orcid.org/0000-0003-4850-5676

Catalogue record

Date deposited: 11 Nov 2008 12:09
Last modified: 06 Jun 2018 12:45

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Contributors

Author: Tao Sun
Author: Camelia Molnar
Author: Donna Davies
Author: Hywel Morgan ORCID iD

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