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Persistent larval sensory neurones are required for the normal development of the adult sensory afferent projections in Drosophila

Williams, Darren W. and Shepherd, David (2002) Persistent larval sensory neurones are required for the normal development of the adult sensory afferent projections in Drosophila Development, 129, (3), pp. 617-624.

Record type: Article

Abstract

We have tested the hypothesis that larval neurones guide growth of adult sensory axons in Drosophila. We show that ablation of larval sensory neurones causes defects in the central projections of adult sensory neurones. Spiralling axons and ectopic projections indicate failure in axon growth guidance.
We show that larval sensory neurones are required for peripheral pathfinding, entry into the CNS and growth guidance within the CNS. Ablation of subsets of neurones shows that larval sensory neurones serve specific guidance roles. Dorsal neurones are required for axon guidance across the midline, whereas lateral neurones are required for posterior growth. We conclude that larval sensory neurones pioneer the assembly of sensory arrays in adults.

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More information

Published date: February 2002
Keywords: laser ablation, axon guidance, metamorphosis, drosophila

Identifiers

Local EPrints ID: 26745
URI: http://eprints.soton.ac.uk/id/eprint/26745
ISSN: 1477-9129
PURE UUID: 1ec6f99e-6578-4e75-a876-db81d5e28e5c
ORCID for David Shepherd: ORCID iD orcid.org/0000-0002-4561-8184

Catalogue record

Date deposited: 10 Apr 2006
Last modified: 24 Jul 2017 16:36

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Contributors

Author: Darren W. Williams
Author: David Shepherd ORCID iD

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