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Persistent larval sensory neurones are required for the normal development of the adult sensory afferent projections in Drosophila

Persistent larval sensory neurones are required for the normal development of the adult sensory afferent projections in Drosophila
Persistent larval sensory neurones are required for the normal development of the adult sensory afferent projections in Drosophila

We have tested the hypothesis that larval neurones guide growth of adult sensory axons in Drosophila. We show that ablation of larval sensory neurones causes defects in the central projections of adult sensory neurones. Spiralling axons and ectopic projections indicate failure in axon growth guidance. We show that larval sensory neurones are required for peripheral pathfinding, entry into the CNS and growth guidance within the CNS. Ablation of subsets of neurones shows that larval sensory neurones serve specific guidance roles. Dorsal neurones are required for axon guidance across the midline, whereas lateral neurones are required for posterior growth. We conclude that larval sensory neurones pioneer the assembly of sensory arrays in adults.

Animals, Drosophila/cytology, Larva/cytology, Laser Therapy, Nervous System/growth & development, Neurons, Afferent/cytology, Wings, Animal/innervation
1477-9129
617-24
Williams, Darren W
af5e44ed-a572-4995-86dd-c5c78d5eadc7
Shepherd, David
11aa6858-d19c-4450-82ff-11dff9dcd9c4
Williams, Darren W
af5e44ed-a572-4995-86dd-c5c78d5eadc7
Shepherd, David
11aa6858-d19c-4450-82ff-11dff9dcd9c4

Williams, Darren W and Shepherd, David (2002) Persistent larval sensory neurones are required for the normal development of the adult sensory afferent projections in Drosophila. Development, 129 (3), 617-24. (doi:10.1242/dev.129.3.617).

Record type: Article

Abstract

We have tested the hypothesis that larval neurones guide growth of adult sensory axons in Drosophila. We show that ablation of larval sensory neurones causes defects in the central projections of adult sensory neurones. Spiralling axons and ectopic projections indicate failure in axon growth guidance. We show that larval sensory neurones are required for peripheral pathfinding, entry into the CNS and growth guidance within the CNS. Ablation of subsets of neurones shows that larval sensory neurones serve specific guidance roles. Dorsal neurones are required for axon guidance across the midline, whereas lateral neurones are required for posterior growth. We conclude that larval sensory neurones pioneer the assembly of sensory arrays in adults.

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Published date: 1 February 2002
Keywords: Animals, Drosophila/cytology, Larva/cytology, Laser Therapy, Nervous System/growth & development, Neurons, Afferent/cytology, Wings, Animal/innervation

Identifiers

Local EPrints ID: 26745
URI: http://eprints.soton.ac.uk/id/eprint/26745
ISSN: 1477-9129
PURE UUID: 1ec6f99e-6578-4e75-a876-db81d5e28e5c

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Date deposited: 10 Apr 2006
Last modified: 08 Nov 2022 17:53

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Contributors

Author: Darren W Williams
Author: David Shepherd

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