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Developmental architecture of adult-specific lineages in the ventral CNS of Drosophila

Record type: Article

In Drosophila most thoracic neuroblasts have two neurogenic periods: an initial brief period during embryogenesis and a second prolonged phase during larval growth. This study focuses on the adult-specific neurons that are born primarily during the second phase of neurogenesis. The fasciculated neurites arising from each cluster of adult-specific neurons express the cell-adhesion protein Neurotactin and they make a complex scaffold of neurite bundles within the thoracic neuropils. Using MARCM clones, we identified the 24 lineages that make up the scaffold of a thoracic hemineuromere. Unlike the earlyborn neurons that are strikingly diverse in both form and function, the adult specific cells in a given lineage are remarkably similar and typically project to only one or two initial targets, which appear to be the bundled neurites from other lineages. Correlated changes in the contacts between the lineages in different segments suggest that these initial contacts have functional significance in terms of future synaptic partners. This paper provides an overall view of the initial connections that eventually lead to the complex connectivity of the bulk of the thoracic neurons.

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Citation

Truman, J.W., Schuppe, H., Shepherd, D. and Williams, D.W. (2004) Developmental architecture of adult-specific lineages in the ventral CNS of Drosophila Development, 131, (20), pp. 5167-5184. (doi:10.1242/dev.01371).

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Published date: October 2004
Keywords: neurogenesis, metamorphosis, neuronal architecture

Identifiers

Local EPrints ID: 26748
URI: http://eprints.soton.ac.uk/id/eprint/26748
ISSN: 1477-9129
PURE UUID: cc5df243-d08b-4465-9e51-204d226252fe

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Date deposited: 10 Apr 2006
Last modified: 17 Jul 2017 16:06

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Contributors

Author: J.W. Truman
Author: H. Schuppe
Author: D. Shepherd
Author: D.W. Williams

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