Detection of DNA-gold nanoparticle hybrids on patterned surfaces
Detection of DNA-gold nanoparticle hybrids on patterned surfaces
An optical diffraction based sensor has been developed for the detection of DNA-gold nanoparticle hybrids. Silicon substrates were patterned with oligonucleotide sequences in the form of a one-dimensional diffraction grating. Complementary sequences are detected by hybridisation with an oligonucleotide functionalised gold nanoparticle label. Detection of the gold nanoparticles is achieved by examining the diffraction efficiency of the diffraction gratings formed by laser illumination.
Weld, A.M.
89c3943c-3c55-4406-b3d7-0fecb527f65c
Yin, H.B.
80f33a1f-d886-4f09-adab-bc65e9125c29
Melvin, T.
fd87f5eb-2bb9-48fa-b7be-7100ace9c50f
Weld, A.M.
89c3943c-3c55-4406-b3d7-0fecb527f65c
Yin, H.B.
80f33a1f-d886-4f09-adab-bc65e9125c29
Melvin, T.
fd87f5eb-2bb9-48fa-b7be-7100ace9c50f
Weld, A.M., Yin, H.B. and Melvin, T.
(2004)
Detection of DNA-gold nanoparticle hybrids on patterned surfaces.
Postgraduate Conference on Biomedical Engineering and Medical Physics (PGBIOMED'04), Southampton.
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Conference or Workshop Item
(Paper)
Abstract
An optical diffraction based sensor has been developed for the detection of DNA-gold nanoparticle hybrids. Silicon substrates were patterned with oligonucleotide sequences in the form of a one-dimensional diffraction grating. Complementary sequences are detected by hybridisation with an oligonucleotide functionalised gold nanoparticle label. Detection of the gold nanoparticles is achieved by examining the diffraction efficiency of the diffraction gratings formed by laser illumination.
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e-pub ahead of print date: August 2004
Venue - Dates:
Postgraduate Conference on Biomedical Engineering and Medical Physics (PGBIOMED'04), Southampton, 2004-08-01
Organisations:
Optoelectronics Research Centre
Identifiers
Local EPrints ID: 267947
URI: http://eprints.soton.ac.uk/id/eprint/267947
PURE UUID: 475d9b08-6766-45bf-b970-00fb5ba6c01a
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Date deposited: 24 Sep 2009 10:19
Last modified: 14 Mar 2024 09:01
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Contributors
Author:
A.M. Weld
Author:
H.B. Yin
Author:
T. Melvin
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