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Detection of DNA-gold nanoparticle hybrids on patterned surfaces

Weld, A.M., Yin, H.B. and Melvin, T. (2004) Detection of DNA-gold nanoparticle hybrids on patterned surfaces At Postgraduate Conference on Biomedical Engineering and Medical Physics (PGBIOMED'04).

Record type: Conference or Workshop Item (Paper)

Abstract

An optical diffraction based sensor has been developed for the detection of DNA-gold nanoparticle hybrids. Silicon substrates were patterned with oligonucleotide sequences in the form of a one-dimensional diffraction grating. Complementary sequences are detected by hybridisation with an oligonucleotide functionalised gold nanoparticle label. Detection of the gold nanoparticles is achieved by examining the diffraction efficiency of the diffraction gratings formed by laser illumination.

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e-pub ahead of print date: August 2004
Venue - Dates: Postgraduate Conference on Biomedical Engineering and Medical Physics (PGBIOMED'04), 2004-08-01
Organisations: Optoelectronics Research Centre

Identifiers

Local EPrints ID: 267947
URI: http://eprints.soton.ac.uk/id/eprint/267947
PURE UUID: 475d9b08-6766-45bf-b970-00fb5ba6c01a

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Date deposited: 24 Sep 2009 10:19
Last modified: 18 Jul 2017 06:58

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Contributors

Author: A.M. Weld
Author: H.B. Yin
Author: T. Melvin

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