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Matching Models to Data in Modelling Morphogen Diffusion

Record type: Conference or Workshop Item (Other)

The mechanism by which spatial patterns are established during embryonic development is usually modelled as passive diffusion of morphogen proteins translated from maternally deposited messenger RNAs. Such diffusion models assume a constant supply of morphogens at the source throughout the establishment of the required profile at steady state. Working with the bicoid morphogen which establishes the anterior-posterior axis in the Drosophila embryo, we note that this constant source assumption is unrealistic since the maternal mRNA is known to decay after a certain time since egg laying. We numerically solve the reaction diffusion equation for one dimensional morphogen propagation and match the resulting solution to measured data. By minimising the squared error between model outputs and measurements published in the FlyEx database, we show how parameters of diffusion rate, mRNA and protein decay constants, and the onset of maternal mRNA decay can be assigned sensible values.

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Citation

Liu, Wei and Niranjan, Mahesan (2009) Matching Models to Data in Modelling Morphogen Diffusion At Machine Learning in Systems Biology.

More information

Published date: September 2009
Additional Information: Event Dates: September, 2009
Venue - Dates: Machine Learning in Systems Biology, 2009-09-01
Organisations: Southampton Wireless Group

Identifiers

Local EPrints ID: 268200
URI: http://eprints.soton.ac.uk/id/eprint/268200
ISBN: 978-952-10-5699-4
PURE UUID: 45651efb-e65f-4a87-a4e4-1e29bf3121b1

Catalogue record

Date deposited: 11 Nov 2009 20:29
Last modified: 18 Jul 2017 06:56

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Contributors

Author: Wei Liu

University divisions

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