Single cell microfluidic impedance cytometry – a review
Single cell microfluidic impedance cytometry – a review
Lab on chip technologies are being developed for multiplexed single cell assays. Impedance offers a simple non-invasive method for counting, identifying and monitoring cellular function. A number of different microfluidic devices for single cell impedance have been developed. These have potential applications ranging from simple cell counting and label-free identification of different cell types or detecting changes in cell morphology after invasion by parasites. Devices have also been developed that trap single cells and continuously record impedance data. This technology has applications in basic research, diagnostics or non-invasively probing cell function at the single-cell level. This review will describe the underlying principles of impedance analysis of particles. It then describes the state of the art in the field of microfluidic impedance flow cytometry. Finally future directions and challenges are discussed.
Sun, Tao
b2f8e932-a7e6-4fe7-94dd-5c4ce725eacb
Morgan, Hywel
de00d59f-a5a2-48c4-a99a-1d5dd7854174
Sun, Tao
b2f8e932-a7e6-4fe7-94dd-5c4ce725eacb
Morgan, Hywel
de00d59f-a5a2-48c4-a99a-1d5dd7854174
Sun, Tao and Morgan, Hywel
(2010)
Single cell microfluidic impedance cytometry – a review.
Microfluidics and Nanofluidics, (Invit.
(Submitted)
Abstract
Lab on chip technologies are being developed for multiplexed single cell assays. Impedance offers a simple non-invasive method for counting, identifying and monitoring cellular function. A number of different microfluidic devices for single cell impedance have been developed. These have potential applications ranging from simple cell counting and label-free identification of different cell types or detecting changes in cell morphology after invasion by parasites. Devices have also been developed that trap single cells and continuously record impedance data. This technology has applications in basic research, diagnostics or non-invasively probing cell function at the single-cell level. This review will describe the underlying principles of impedance analysis of particles. It then describes the state of the art in the field of microfluidic impedance flow cytometry. Finally future directions and challenges are discussed.
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Submitted date: 2010
Organisations:
Nanoelectronics and Nanotechnology
Identifiers
Local EPrints ID: 268366
URI: http://eprints.soton.ac.uk/id/eprint/268366
ISSN: 1613-4982
PURE UUID: f51fae41-cab6-418b-984b-2510a48e0ced
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Date deposited: 11 Jan 2010 22:20
Last modified: 11 Dec 2021 03:55
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Contributors
Author:
Tao Sun
Author:
Hywel Morgan
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