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Role of tumor necrosis factor alpha in asthma

Role of tumor necrosis factor alpha in asthma
Role of tumor necrosis factor alpha in asthma
Asthma is a heterogeneous disease in which various cytokines orchestrate airway inflammation. Tumor necrosis alpha (TNF-alpha) is a proinflammatory cytokine that has been implicated in the modulation of inflammation in various diseases, including asthma. Although TNF-alpha blocking strategies have been an effective therapeutic modality in diseases such as rheumatoid arthritis, their role in asthma and the effects of the blockade in asthma is poorly understood. This article examines the role of TNF-alpha in asthma and the effects of blocking TNF-alpha as a possible therapeutic option in patients with severe corticosteroid-dependent asthma.
0889-8561
583-597
Babu, K. Suresh
abf81db8-ccac-40e0-94b7-d5c9b7049ffa
Davies, Donna E.
7de8fdc7-3640-4e3a-aa91-d0e03f990c38
Holgate, Stephen T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Babu, K. Suresh
abf81db8-ccac-40e0-94b7-d5c9b7049ffa
Davies, Donna E.
7de8fdc7-3640-4e3a-aa91-d0e03f990c38
Holgate, Stephen T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc

Babu, K. Suresh, Davies, Donna E. and Holgate, Stephen T. (2004) Role of tumor necrosis factor alpha in asthma. Immunology and Allergy Clinics of North America, 24 (4), 583-597.

Record type: Article

Abstract

Asthma is a heterogeneous disease in which various cytokines orchestrate airway inflammation. Tumor necrosis alpha (TNF-alpha) is a proinflammatory cytokine that has been implicated in the modulation of inflammation in various diseases, including asthma. Although TNF-alpha blocking strategies have been an effective therapeutic modality in diseases such as rheumatoid arthritis, their role in asthma and the effects of the blockade in asthma is poorly understood. This article examines the role of TNF-alpha in asthma and the effects of blocking TNF-alpha as a possible therapeutic option in patients with severe corticosteroid-dependent asthma.

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Published date: 2004

Identifiers

Local EPrints ID: 26920
URI: https://eprints.soton.ac.uk/id/eprint/26920
ISSN: 0889-8561
PURE UUID: c30b1c9a-76ea-4906-8556-8b8d7c5ea54c

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Date deposited: 25 Apr 2006
Last modified: 04 Nov 2017 08:22

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