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Peak expiratory flow changes during experimental rhinovirus infection

Peak expiratory flow changes during experimental rhinovirus infection
Peak expiratory flow changes during experimental rhinovirus infection
Rhinovirus (RV) colds are associated with asthma exacerbations and experimental infections are commonly used to investigate the mechanisms involved. However, a temporal association between experimental RV infections and falls in peak expiratory flow (PEF) have not been demonstrated. PEF was measured in 22 volunteers (11 normal, five atopic, six atopic asthmatic) who developed RV serotype 16 colds after inoculation. PEF was measured twice daily for 2 weeks prior and 6 weeks after RV infection and episodes of respiratory morbidity based on changes in PEF were defined using validated criteria. Six significant reductions in PEF were temporally related to the RV infections (in two (18%) normal, one (20%) atopic, three (50%) atopic asthmatic subjects, p=0.1) and occurred 4-9 days (median 6) after inoculation. Mean+/-SEM PEF at day 6 was 87.8+/-1.8% of the predicted value in the six subjects with reductions versus 99.4+/-1.4% pred in those without (p=0.01).
Symptom scores were significantly different at day 6 in the two groups (10.6+/-1.9 versus 6.8+/-1.0, p=0.03), but no differences were noted in the viral culture scores and changes in nasal albumin. In subjects with significant PEF reduction, the decrease in the provocative concentration causing a 20% fall in the forced expiratory volume in one second (FEV1) (PC20) was 1.7+/-1.3 mg x mL(-1) versus 1.2+/-1.1 mg x mL(-1) in the negative group (p=0.06). The degree of seroconversion to RV was significantly higher in the group with reduced PEF (median change dilutions 8 versus 4, p=0.02). The results of the present study suggest that rhinovirus-associated, respiratory morbidity occurs during experimental infection in some but not all normal and asthmatic subjects and also that experimental colds are a valid model for the study of rhinovirus-associated airway symptoms and asthma exacerbations.
asthma, experimental infection, peak expiratory flow, rhinovirus
0903-1936
980-985
Bardin, P.G.
92b18c26-9432-4605-954d-85e6d3f1cdbe
Fraenkel, D.J.G.
cc820aaa-0361-4b90-8b36-f10438984f20
VanSchalkwyk, E.M.
6a1d5bfa-c5f0-401e-a340-7a3a802a0aed
Holgate, S.T.
48e197d1-3681-43c1-9a3e-478311f6618d
Johnston, S.L.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Bardin, P.G.
92b18c26-9432-4605-954d-85e6d3f1cdbe
Fraenkel, D.J.G.
cc820aaa-0361-4b90-8b36-f10438984f20
VanSchalkwyk, E.M.
6a1d5bfa-c5f0-401e-a340-7a3a802a0aed
Holgate, S.T.
48e197d1-3681-43c1-9a3e-478311f6618d
Johnston, S.L.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc

Bardin, P.G., Fraenkel, D.J.G., VanSchalkwyk, E.M., Holgate, S.T. and Johnston, S.L. (2000) Peak expiratory flow changes during experimental rhinovirus infection. European Respiratory Journal, 16 (5), 980-985.

Record type: Article

Abstract

Rhinovirus (RV) colds are associated with asthma exacerbations and experimental infections are commonly used to investigate the mechanisms involved. However, a temporal association between experimental RV infections and falls in peak expiratory flow (PEF) have not been demonstrated. PEF was measured in 22 volunteers (11 normal, five atopic, six atopic asthmatic) who developed RV serotype 16 colds after inoculation. PEF was measured twice daily for 2 weeks prior and 6 weeks after RV infection and episodes of respiratory morbidity based on changes in PEF were defined using validated criteria. Six significant reductions in PEF were temporally related to the RV infections (in two (18%) normal, one (20%) atopic, three (50%) atopic asthmatic subjects, p=0.1) and occurred 4-9 days (median 6) after inoculation. Mean+/-SEM PEF at day 6 was 87.8+/-1.8% of the predicted value in the six subjects with reductions versus 99.4+/-1.4% pred in those without (p=0.01).
Symptom scores were significantly different at day 6 in the two groups (10.6+/-1.9 versus 6.8+/-1.0, p=0.03), but no differences were noted in the viral culture scores and changes in nasal albumin. In subjects with significant PEF reduction, the decrease in the provocative concentration causing a 20% fall in the forced expiratory volume in one second (FEV1) (PC20) was 1.7+/-1.3 mg x mL(-1) versus 1.2+/-1.1 mg x mL(-1) in the negative group (p=0.06). The degree of seroconversion to RV was significantly higher in the group with reduced PEF (median change dilutions 8 versus 4, p=0.02). The results of the present study suggest that rhinovirus-associated, respiratory morbidity occurs during experimental infection in some but not all normal and asthmatic subjects and also that experimental colds are a valid model for the study of rhinovirus-associated airway symptoms and asthma exacerbations.

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More information

Published date: 2000
Keywords: asthma, experimental infection, peak expiratory flow, rhinovirus

Identifiers

Local EPrints ID: 26928
URI: http://eprints.soton.ac.uk/id/eprint/26928
ISSN: 0903-1936
PURE UUID: dbca529c-3a61-4678-b3b4-26e799771cea

Catalogue record

Date deposited: 25 Apr 2006
Last modified: 08 Jan 2022 03:50

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Contributors

Author: P.G. Bardin
Author: D.J.G. Fraenkel
Author: E.M. VanSchalkwyk
Author: S.T. Holgate
Author: S.L. Johnston

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