Lack of association of HLA class I genes and TNFα-308 polymorphism in toluene diisocyanate-induced asthma

Beghé, B., Padoan, M., Moss, C.T., Barton, S.J., Holloway, J.W., Holgate, S.T., Howell, W.M. and Mapp, C.E. (2004) Lack of association of HLA class I genes and TNFα-308 polymorphism in toluene diisocyanate-induced asthma. Allergy, 59 (1), 61-64. (doi:10.1046/j.1398-9995.2003.00352.x).

Abstract

Background: Toluene diisocyanate (TDI)-induced asthma is a common cause of occupational asthma and it affects 5–15% of the exposed population suggesting an underlying genetic susceptibility.
Methods: To investigate the role of genetic factors in the development of TDI-induced asthma, we analyzed the distribution of human leukocyte antigen (HLA) class I genes and of tumor necrosis factor (TNF)-? A-308G polymorphism in 142 patients with TDI-induced asthma and in 50 asymptomatic exposed subjects.
Results: Neither the distribution of HLA class I antigens nor the distribution of TNF-? A-308G polymorphism was different between patients with TDI-induced asthma and asymptomatic exposed subjects.
Conclusions: These results suggest that HLA class I antigens and TNF-? A-308G are not associated with susceptibility or resistance to the development of TDI-induced asthma.

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Contributors

Author: S.J. Barton

Author: J.W. Holloway

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