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Lack of association of HLA class I genes and TNFα-308 polymorphism in toluene diisocyanate-induced asthma

Lack of association of HLA class I genes and TNFα-308 polymorphism in toluene diisocyanate-induced asthma
Lack of association of HLA class I genes and TNFα-308 polymorphism in toluene diisocyanate-induced asthma
Background: Toluene diisocyanate (TDI)-induced asthma is a common cause of occupational asthma and it affects 5–15% of the exposed population suggesting an underlying genetic susceptibility.
Methods: To investigate the role of genetic factors in the development of TDI-induced asthma, we analyzed the distribution of human leukocyte antigen (HLA) class I genes and of tumor necrosis factor (TNF)-? A-308G polymorphism in 142 patients with TDI-induced asthma and in 50 asymptomatic exposed subjects.
Results: Neither the distribution of HLA class I antigens nor the distribution of TNF-? A-308G polymorphism was different between patients with TDI-induced asthma and asymptomatic exposed subjects.
Conclusions: These results suggest that HLA class I antigens and TNF-? A-308G are not associated with susceptibility or resistance to the development of TDI-induced asthma.
0105-4538
61-64
Beghé, B.
c20830d1-e2ba-4ddd-af37-7c49dc82311a
Padoan, M.
7a51ded9-5fcc-4a09-be01-df623d8d7162
Moss, C.T.
da159b1e-183d-4257-9042-22bdfb0328de
Barton, S.J.
4f674382-ca0b-44ad-9670-e71a0b134ef0
Holloway, J.W.
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
Holgate, S.T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Howell, W.M.
dc6fe896-2230-4cf3-9862-f979cb872454
Mapp, C.E.
bb013a54-9508-406f-b29a-2957bdffbd2e
Beghé, B.
c20830d1-e2ba-4ddd-af37-7c49dc82311a
Padoan, M.
7a51ded9-5fcc-4a09-be01-df623d8d7162
Moss, C.T.
da159b1e-183d-4257-9042-22bdfb0328de
Barton, S.J.
4f674382-ca0b-44ad-9670-e71a0b134ef0
Holloway, J.W.
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
Holgate, S.T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Howell, W.M.
dc6fe896-2230-4cf3-9862-f979cb872454
Mapp, C.E.
bb013a54-9508-406f-b29a-2957bdffbd2e

Beghé, B., Padoan, M., Moss, C.T., Barton, S.J., Holloway, J.W., Holgate, S.T., Howell, W.M. and Mapp, C.E. (2004) Lack of association of HLA class I genes and TNFα-308 polymorphism in toluene diisocyanate-induced asthma. Allergy, 59 (1), 61-64. (doi:10.1046/j.1398-9995.2003.00352.x).

Record type: Article

Abstract

Background: Toluene diisocyanate (TDI)-induced asthma is a common cause of occupational asthma and it affects 5–15% of the exposed population suggesting an underlying genetic susceptibility.
Methods: To investigate the role of genetic factors in the development of TDI-induced asthma, we analyzed the distribution of human leukocyte antigen (HLA) class I genes and of tumor necrosis factor (TNF)-? A-308G polymorphism in 142 patients with TDI-induced asthma and in 50 asymptomatic exposed subjects.
Results: Neither the distribution of HLA class I antigens nor the distribution of TNF-? A-308G polymorphism was different between patients with TDI-induced asthma and asymptomatic exposed subjects.
Conclusions: These results suggest that HLA class I antigens and TNF-? A-308G are not associated with susceptibility or resistance to the development of TDI-induced asthma.

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Published date: 2004

Identifiers

Local EPrints ID: 26933
URI: https://eprints.soton.ac.uk/id/eprint/26933
ISSN: 0105-4538
PURE UUID: 6bff645f-2393-4a0d-a6ba-8ff7159391b5
ORCID for S.J. Barton: ORCID iD orcid.org/0000-0003-4963-4242
ORCID for J.W. Holloway: ORCID iD orcid.org/0000-0001-9998-0464

Catalogue record

Date deposited: 25 Apr 2006
Last modified: 06 Jun 2018 12:59

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