The University of Southampton
University of Southampton Institutional Repository

Pulmonary and gastric surfactants. A comparison of the effect of surface requirements on function and phospholipid composition

Bernhard, Wolfgang, Postle, Anthony D., Rau, Gunnar A. and Freihorst, Joachim (2001) Pulmonary and gastric surfactants. A comparison of the effect of surface requirements on function and phospholipid composition Comparative Biochemistry and Physiology. Part A: Molecular & Integrative Physiology, 129, (1), pp. 173-182. (doi:10.1016/S1095-6433(01)00314-2).

Record type: Article

Abstract

Surfactant is present in the alveoli and conductive airways of mammalian lungs. The presence of surface active agents was, moreover, demonstrated for avian tubular lungs and for the stomach and intestine. As the surface characteristics of these organs differ from each other, their surfactants possess distinct biochemical and functional characteristics. In the stomach so-called ‘gastric surfactant’ forms a hydrophobic barrier to protect the mucosa against acid back-diffusion. For this purpose gastric mucosal cells secrete unsaturated phosphatidylcholines (PC), but no dipalmitoyl-PC (PC16:0/16:0). By contrast, surfactant from conductive airways, lung alveoli and tubular avian lungs contain PC16:0/16:0 as their main component in similar concentrations. Hence, there is no biochemical relation between gastric and pulmonary surfactant. Alveolar surfactant, being designed for preventing alveolar collapse under the highly dynamic conditions of an oscillating alveolus, easily reaches values of <5 mN/m upon cyclic compression. Surfactants from tubular air-exposed structures, however, like the conductive airways of mammalian lungs and the exclusively tubular avian lung, display inferior compressibility as they only reach minimal surface tension values of approximately 20 mN/m. Hence, the highly dynamic properties of alveolar surfactant do not apply for surfactants designed for air–liquid interfaces of tubular lung structures.

Full text not available from this repository.

More information

Published date: 2001
Keywords: air capillaries, airway surfactant, alveolar surfactant, bird surfactant, dipalmitoylphosphatidylcholine, gastric surfactant, phospholipid, pulsating bubble surfactometer, surfactant function

Identifiers

Local EPrints ID: 26940
URI: http://eprints.soton.ac.uk/id/eprint/26940
PURE UUID: d16f92c1-f0c8-45f1-a1c0-e0dbb638fac0
ORCID for Anthony D. Postle: ORCID iD orcid.org/0000-0001-7361-0756

Catalogue record

Date deposited: 25 Apr 2006
Last modified: 17 Jul 2017 16:05

Export record

Altmetrics

Contributors

Author: Wolfgang Bernhard
Author: Gunnar A. Rau
Author: Joachim Freihorst

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×