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Effects of local blood flow on the percutaneous absorption of the organophosphorus compound malathion: a microdialysis study in man

Record type: Article

Malathion [O,O-dimethyl-S-(1,2-dicarbethoxyethyl)phosphorodithioate] is an organophosphorus insecticide widely used in veterinary medicine and in humans for the treatment of lice. In this study, the rate of the percutaneous absorption of malathion has been measured in human skin, in vivo, using microdialysis. Malathion was detected in tissue dialysate within 30 min of its topical application to the skin of the volar surface of the forearm of healthy volunteers. The concentration of malathion in dialysate increased with lengthening duration of exposure to reach a steady state concentration at 2 h. Prolonged exposure to malathion caused a marked and long-lasting erythema localized to the area of contact.
There was no evidence of local tissue oedema or of a neurogenically mediated flare or itch response following topical application. Reducing skin blood flow by the addition of the vasoconstrictor noradrenaline to the dialysis probe perfusate caused an eight-fold increase in the recovery of malathion in the dialysate, which failed to reach a steady state within 5 h. Together, these data confirm that malathion can be absorbed percutaneously and that its distribution within the cutaneous tissue space is influenced by local skin blood flow. They suggest that the increase in skin blood flow caused by malathion may itself play a significant role in enhancing its systemic uptake.

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Citation

Boutsiouki, Paraskevi, Thompson, John P. and Clough, Geraldine F. (2001) Effects of local blood flow on the percutaneous absorption of the organophosphorus compound malathion: a microdialysis study in man Archives of Toxicology, 75, (6), pp. 321-328. (doi:10.1007/s002040100245).

More information

Published date: 2001
Keywords: organophosphates, malathion, skin, blood flow, microdialysis, laser doppler imaging

Identifiers

Local EPrints ID: 26952
URI: http://eprints.soton.ac.uk/id/eprint/26952
ISSN: 0340-5761
PURE UUID: 6e19a9e1-2d38-4ae7-b717-3b4ab10d3b98
ORCID for Geraldine F. Clough: ORCID iD orcid.org/0000-0002-6226-8964

Catalogue record

Date deposited: 25 Apr 2006
Last modified: 17 Jul 2017 16:05

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Contributors

Author: Paraskevi Boutsiouki
Author: John P. Thompson

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