The University of Southampton
University of Southampton Institutional Repository

Effects of local blood flow on the percutaneous absorption of the organophosphorus compound malathion: a microdialysis study in man

Effects of local blood flow on the percutaneous absorption of the organophosphorus compound malathion: a microdialysis study in man
Effects of local blood flow on the percutaneous absorption of the organophosphorus compound malathion: a microdialysis study in man
Malathion [O,O-dimethyl-S-(1,2-dicarbethoxyethyl)phosphorodithioate] is an organophosphorus insecticide widely used in veterinary medicine and in humans for the treatment of lice. In this study, the rate of the percutaneous absorption of malathion has been measured in human skin, in vivo, using microdialysis. Malathion was detected in tissue dialysate within 30 min of its topical application to the skin of the volar surface of the forearm of healthy volunteers. The concentration of malathion in dialysate increased with lengthening duration of exposure to reach a steady state concentration at 2 h. Prolonged exposure to malathion caused a marked and long-lasting erythema localized to the area of contact.
There was no evidence of local tissue oedema or of a neurogenically mediated flare or itch response following topical application. Reducing skin blood flow by the addition of the vasoconstrictor noradrenaline to the dialysis probe perfusate caused an eight-fold increase in the recovery of malathion in the dialysate, which failed to reach a steady state within 5 h. Together, these data confirm that malathion can be absorbed percutaneously and that its distribution within the cutaneous tissue space is influenced by local skin blood flow. They suggest that the increase in skin blood flow caused by malathion may itself play a significant role in enhancing its systemic uptake.
organophosphates, malathion, skin, blood flow, microdialysis, laser doppler imaging
0340-5761
321-328
Boutsiouki, Paraskevi
7bcd1b5c-184a-4624-9419-0c2c78faa0df
Thompson, John P.
220fe255-92bb-426c-8419-96c5f93975a4
Clough, Geraldine F.
9f19639e-a929-4976-ac35-259f9011c494
Boutsiouki, Paraskevi
7bcd1b5c-184a-4624-9419-0c2c78faa0df
Thompson, John P.
220fe255-92bb-426c-8419-96c5f93975a4
Clough, Geraldine F.
9f19639e-a929-4976-ac35-259f9011c494

Boutsiouki, Paraskevi, Thompson, John P. and Clough, Geraldine F. (2001) Effects of local blood flow on the percutaneous absorption of the organophosphorus compound malathion: a microdialysis study in man. Archives of Toxicology, 75 (6), 321-328. (doi:10.1007/s002040100245).

Record type: Article

Abstract

Malathion [O,O-dimethyl-S-(1,2-dicarbethoxyethyl)phosphorodithioate] is an organophosphorus insecticide widely used in veterinary medicine and in humans for the treatment of lice. In this study, the rate of the percutaneous absorption of malathion has been measured in human skin, in vivo, using microdialysis. Malathion was detected in tissue dialysate within 30 min of its topical application to the skin of the volar surface of the forearm of healthy volunteers. The concentration of malathion in dialysate increased with lengthening duration of exposure to reach a steady state concentration at 2 h. Prolonged exposure to malathion caused a marked and long-lasting erythema localized to the area of contact.
There was no evidence of local tissue oedema or of a neurogenically mediated flare or itch response following topical application. Reducing skin blood flow by the addition of the vasoconstrictor noradrenaline to the dialysis probe perfusate caused an eight-fold increase in the recovery of malathion in the dialysate, which failed to reach a steady state within 5 h. Together, these data confirm that malathion can be absorbed percutaneously and that its distribution within the cutaneous tissue space is influenced by local skin blood flow. They suggest that the increase in skin blood flow caused by malathion may itself play a significant role in enhancing its systemic uptake.

This record has no associated files available for download.

More information

Published date: 2001
Keywords: organophosphates, malathion, skin, blood flow, microdialysis, laser doppler imaging

Identifiers

Local EPrints ID: 26952
URI: http://eprints.soton.ac.uk/id/eprint/26952
ISSN: 0340-5761
PURE UUID: 6e19a9e1-2d38-4ae7-b717-3b4ab10d3b98
ORCID for Geraldine F. Clough: ORCID iD orcid.org/0000-0002-6226-8964

Catalogue record

Date deposited: 25 Apr 2006
Last modified: 16 Mar 2024 02:54

Export record

Altmetrics

Contributors

Author: Paraskevi Boutsiouki
Author: John P. Thompson

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×