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Formation of artificial lipid bilayers using droplet dielectrophoresis

Formation of artificial lipid bilayers using droplet dielectrophoresis
Formation of artificial lipid bilayers using droplet dielectrophoresis
We describe the formation of artificial bilayer lipid membranes (BLMs) by the controlled, electrical manipulation of aqueous droplets immersed in a lipid-alkane solution. Droplet movement was generated using dielectrophoresis on planar microelectrodes covered in a thin insulator. Droplets, surrounded by lipid monolayers, were brought into contact and spontaneously formed a BLM. The method produced BLMs suitable for single-channel recording of membrane protein activity and the technique can be extended to create programmable BLM arrays and networks.
1473-0197
1617-1620
Aghdaei, Sara
6bb71f1d-c8be-458c-a787-35336308282e
Sandison, Mairi E.
90477e5a-2af6-44b1-8ea8-ae4515594c60
Zagnoni, Michele
abfb96d5-0d3c-4b23-864b-b1212f6d5a42
Green, Nicolas G
d9b47269-c426-41fd-a41d-5f4579faa581
Morgan, Hywel
de00d59f-a5a2-48c4-a99a-1d5dd7854174
Aghdaei, Sara
6bb71f1d-c8be-458c-a787-35336308282e
Sandison, Mairi E.
90477e5a-2af6-44b1-8ea8-ae4515594c60
Zagnoni, Michele
abfb96d5-0d3c-4b23-864b-b1212f6d5a42
Green, Nicolas G
d9b47269-c426-41fd-a41d-5f4579faa581
Morgan, Hywel
de00d59f-a5a2-48c4-a99a-1d5dd7854174

Aghdaei, Sara, Sandison, Mairi E., Zagnoni, Michele, Green, Nicolas G and Morgan, Hywel (2008) Formation of artificial lipid bilayers using droplet dielectrophoresis. Lab on a Chip, 8 (10), 1617-1620. (doi:10.1039/B807374K). (PMID:18813381)

Record type: Article

Abstract

We describe the formation of artificial bilayer lipid membranes (BLMs) by the controlled, electrical manipulation of aqueous droplets immersed in a lipid-alkane solution. Droplet movement was generated using dielectrophoresis on planar microelectrodes covered in a thin insulator. Droplets, surrounded by lipid monolayers, were brought into contact and spontaneously formed a BLM. The method produced BLMs suitable for single-channel recording of membrane protein activity and the technique can be extended to create programmable BLM arrays and networks.

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e-pub ahead of print date: 13 August 2008
Published date: 2008
Organisations: Electronics & Computer Science

Identifiers

Local EPrints ID: 269536
URI: https://eprints.soton.ac.uk/id/eprint/269536
ISSN: 1473-0197
PURE UUID: 706d431b-413a-4196-bb18-81c0d8ca4c7a
ORCID for Nicolas G Green: ORCID iD orcid.org/0000-0001-9230-4455
ORCID for Hywel Morgan: ORCID iD orcid.org/0000-0003-4850-5676

Catalogue record

Date deposited: 21 Apr 2010 07:46
Last modified: 20 Jul 2019 00:59

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Contributors

Author: Sara Aghdaei
Author: Mairi E. Sandison
Author: Michele Zagnoni
Author: Nicolas G Green ORCID iD
Author: Hywel Morgan ORCID iD

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