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Mast-cell infiltration of airway smooth muscle in asthma

Mast-cell infiltration of airway smooth muscle in asthma
Mast-cell infiltration of airway smooth muscle in asthma
Background Asthma and eosinophilic bronchitis are characterized by similar inflammatory infiltrates in the submucosa of the lower airway. However, eosinophilic bronchitis differs from asthma in that there is no variable airflow obstruction or airway hyperresponsiveness in the former condition. We tested the hypothesis that there were differences between the two conditions in the microlocalization of mast cells within the airway smooth muscle.
Methods Immunohistochemical analysis of bronchial-biopsy specimens was completed in 17 subjects with asthma, 13 subjects with eosinophilic bronchitis, and 11 normal controls recruited from two centers.
Results Both groups with disease had a similar degree of submucosal eosinophilia and thickening of the basement membrane and lamina reticularis. By contrast, the number of tryptase-positive mast cells in the bundles of airway smooth muscle from subjects with asthma (median, 5.1 mast cells per square millimeter of smooth muscle [range, 0 to 33.3]) was substantially higher than that in subjects with eosinophilic bronchitis (median, 0 mast cells per square millimeter; range, 0 to 4.8) and that in normal controls (median, 0 mast cells per square millimeter [range, 0 to 6.4]; P<0.001 for the comparison among the three groups). T cells and eosinophils were not usually seen in the airway smooth muscle in any of the groups.
Conclusions The infiltration of airway smooth muscle by mast cells is associated with the disordered airway function found in asthma.
1699-1705
Brightling, Christopher E.
b3f869e5-2e62-4a1f-868c-2de15875f55e
Bradding, Peter
9cbfd3d1-1bf2-484f-849f-0bf4ffbacc19
Symon, Fiona A.
14302398-2306-4740-b6d2-b86cc7b20f34
Holgate, Stephen T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Wardlaw, Andrew J.
4fcd092d-61df-4eae-a5f6-50c506fe6a64
Pavord, Ian D.
ee414b70-d199-4271-be4f-408da5bcad8f
Brightling, Christopher E.
b3f869e5-2e62-4a1f-868c-2de15875f55e
Bradding, Peter
9cbfd3d1-1bf2-484f-849f-0bf4ffbacc19
Symon, Fiona A.
14302398-2306-4740-b6d2-b86cc7b20f34
Holgate, Stephen T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Wardlaw, Andrew J.
4fcd092d-61df-4eae-a5f6-50c506fe6a64
Pavord, Ian D.
ee414b70-d199-4271-be4f-408da5bcad8f

Brightling, Christopher E., Bradding, Peter, Symon, Fiona A., Holgate, Stephen T., Wardlaw, Andrew J. and Pavord, Ian D. (2002) Mast-cell infiltration of airway smooth muscle in asthma. New England Journal of Medicine, 346 (22), 1699-1705.

Record type: Article

Abstract

Background Asthma and eosinophilic bronchitis are characterized by similar inflammatory infiltrates in the submucosa of the lower airway. However, eosinophilic bronchitis differs from asthma in that there is no variable airflow obstruction or airway hyperresponsiveness in the former condition. We tested the hypothesis that there were differences between the two conditions in the microlocalization of mast cells within the airway smooth muscle.
Methods Immunohistochemical analysis of bronchial-biopsy specimens was completed in 17 subjects with asthma, 13 subjects with eosinophilic bronchitis, and 11 normal controls recruited from two centers.
Results Both groups with disease had a similar degree of submucosal eosinophilia and thickening of the basement membrane and lamina reticularis. By contrast, the number of tryptase-positive mast cells in the bundles of airway smooth muscle from subjects with asthma (median, 5.1 mast cells per square millimeter of smooth muscle [range, 0 to 33.3]) was substantially higher than that in subjects with eosinophilic bronchitis (median, 0 mast cells per square millimeter; range, 0 to 4.8) and that in normal controls (median, 0 mast cells per square millimeter [range, 0 to 6.4]; P<0.001 for the comparison among the three groups). T cells and eosinophils were not usually seen in the airway smooth muscle in any of the groups.
Conclusions The infiltration of airway smooth muscle by mast cells is associated with the disordered airway function found in asthma.

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Published date: 2002

Identifiers

Local EPrints ID: 26961
URI: http://eprints.soton.ac.uk/id/eprint/26961
PURE UUID: ae503bb3-00a2-4a0c-969c-8a7b18178876

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Date deposited: 25 Apr 2006
Last modified: 15 Jul 2019 19:13

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