Basic science and pathophysiology of ocular allergy
Basic science and pathophysiology of ocular allergy
Ocular allergy includes several clinical subtypes ranging from the mild seasonal allergic conjunctivitis to the potentially sight-threatening atopic keratoconjunctivitis. Current therapies, particularly for the severe forms of disease, need to be more localized and with fewer side effects. For this to be achieved, it requires a better understanding of the basic mechanisms involved. In this chapter, recent findings are discussed that suggest that it is important to take an integrated approach, including both immune and structural elements of the eye. This provides potential new strategies for therapy, addressing the influence of structural cells in disease. These might influence the immune processes that take place and, as the structural cells are precisely localized, topical application is likely to be effective.
326-331
Calder, Virginia L.
87d1cde1-0662-4b24-9a18-aaf103e903c3
Lackie, Peter M.
4afbbe1a-22a6-4ceb-8cad-f3696dc43a7a
2004
Calder, Virginia L.
87d1cde1-0662-4b24-9a18-aaf103e903c3
Lackie, Peter M.
4afbbe1a-22a6-4ceb-8cad-f3696dc43a7a
Calder, Virginia L. and Lackie, Peter M.
(2004)
Basic science and pathophysiology of ocular allergy.
Current Allergy and Asthma Reports, 4 (4), .
Abstract
Ocular allergy includes several clinical subtypes ranging from the mild seasonal allergic conjunctivitis to the potentially sight-threatening atopic keratoconjunctivitis. Current therapies, particularly for the severe forms of disease, need to be more localized and with fewer side effects. For this to be achieved, it requires a better understanding of the basic mechanisms involved. In this chapter, recent findings are discussed that suggest that it is important to take an integrated approach, including both immune and structural elements of the eye. This provides potential new strategies for therapy, addressing the influence of structural cells in disease. These might influence the immune processes that take place and, as the structural cells are precisely localized, topical application is likely to be effective.
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Published date: 2004
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Local EPrints ID: 26977
URI: http://eprints.soton.ac.uk/id/eprint/26977
ISSN: 1529-7322
PURE UUID: c79aa067-a8d6-435d-9427-64106d0d6c02
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Date deposited: 26 Apr 2006
Last modified: 08 Jan 2022 02:40
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Author:
Virginia L. Calder
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