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The effects of Mycobacterium vaccae on allergen-induced airway responses in atopic asthma

The effects of Mycobacterium vaccae on allergen-induced airway responses in atopic asthma
The effects of Mycobacterium vaccae on allergen-induced airway responses in atopic asthma
T-helper (Th)2 cytokines play a central role in asthma. Therefore, a double-blind randomised study was conducted to investigate whether heat-killed Mycobacterium vaccae (SRL172), a potent downregulator of Th2 cytokines, can reduce allergen-induced airway responses in patients with atopic asthma.
A total 24 male asthmatics participated in this study. A bronchial allergen challenge was performed along with early (EAR) and late asthmatic responses (LAR) 2 weeks before and 3 weeks after a single intradermal injection of SRL172 or placebo. Before and after treatment, serum immunoglobulin (Ig)E levels and in vitro production of interleukin (IL)-5 by peripheral blood lymphocytes were studied.
Neither treatment affected the EAR. SRL172 caused a mean 34% reduction of the area under the curve of the forced expiratory volume in one second (FEV1) changes during the LAR, which failed to reach conventional statistical significance when compared with placebo. SRL172 also caused a mean 25% decrease in the maximum fall in FEV1 during LAR, but this was not significantly different from placebo. SRL172 caused a reduction in serum IgE and IL-5 synthesis in vitro 3 weeks post-treatment (p=0.07).
This study shows a trend toward significance for the effects of heat-killed Mycobacterium vaccae (SRL172) on allergen-induced airway responses. Further clinical trials, involving multiple dosing, are needed.
allergen challenge, asthma, interleukin-5, mycobacterium vaccae
0903-1936
287-293
Camporota, L.
4307218b-89bd-47d7-91cd-5de630425dde
Corkhill, A.
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Long, H.
bbf1608b-53fb-4afa-8f8a-baca9ad1a7d8
Lordan, J.
c7a31d0c-ffa9-4073-a5e5-4ca166e9df14
Stanciu, L.
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Tuckwell, N.
bf211bf9-267b-44d3-918d-938d4841bfcb
Cross, A.
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Stanford, J.L.
e3076df4-bed0-420a-808d-c8cc0daf6ad6
Rook, G.A.
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Holgate, S.T.
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Djukanovic, R.
d9a45ee7-6a80-4d84-a0ed-10962660a98d
Camporota, L.
4307218b-89bd-47d7-91cd-5de630425dde
Corkhill, A.
0c74f67c-67b0-46c0-b362-53875c47c09c
Long, H.
bbf1608b-53fb-4afa-8f8a-baca9ad1a7d8
Lordan, J.
c7a31d0c-ffa9-4073-a5e5-4ca166e9df14
Stanciu, L.
33792ce5-2f72-41e1-afe1-887951e74f22
Tuckwell, N.
bf211bf9-267b-44d3-918d-938d4841bfcb
Cross, A.
7ed6cfa9-4774-4f06-a93c-7eb88ae823a0
Stanford, J.L.
e3076df4-bed0-420a-808d-c8cc0daf6ad6
Rook, G.A.
6916a3d9-7bda-43bb-ac72-fe90d5154ab0
Holgate, S.T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Djukanovic, R.
d9a45ee7-6a80-4d84-a0ed-10962660a98d

Camporota, L., Corkhill, A., Long, H., Lordan, J., Stanciu, L., Tuckwell, N., Cross, A., Stanford, J.L., Rook, G.A., Holgate, S.T. and Djukanovic, R. (2003) The effects of Mycobacterium vaccae on allergen-induced airway responses in atopic asthma. European Respiratory Journal, 21 (2), 287-293. (doi:10.1183/09031936.03.00042103).

Record type: Article

Abstract

T-helper (Th)2 cytokines play a central role in asthma. Therefore, a double-blind randomised study was conducted to investigate whether heat-killed Mycobacterium vaccae (SRL172), a potent downregulator of Th2 cytokines, can reduce allergen-induced airway responses in patients with atopic asthma.
A total 24 male asthmatics participated in this study. A bronchial allergen challenge was performed along with early (EAR) and late asthmatic responses (LAR) 2 weeks before and 3 weeks after a single intradermal injection of SRL172 or placebo. Before and after treatment, serum immunoglobulin (Ig)E levels and in vitro production of interleukin (IL)-5 by peripheral blood lymphocytes were studied.
Neither treatment affected the EAR. SRL172 caused a mean 34% reduction of the area under the curve of the forced expiratory volume in one second (FEV1) changes during the LAR, which failed to reach conventional statistical significance when compared with placebo. SRL172 also caused a mean 25% decrease in the maximum fall in FEV1 during LAR, but this was not significantly different from placebo. SRL172 caused a reduction in serum IgE and IL-5 synthesis in vitro 3 weeks post-treatment (p=0.07).
This study shows a trend toward significance for the effects of heat-killed Mycobacterium vaccae (SRL172) on allergen-induced airway responses. Further clinical trials, involving multiple dosing, are needed.

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More information

Published date: 2003
Keywords: allergen challenge, asthma, interleukin-5, mycobacterium vaccae

Identifiers

Local EPrints ID: 26979
URI: https://eprints.soton.ac.uk/id/eprint/26979
ISSN: 0903-1936
PURE UUID: b11aac92-8e67-491f-b8d5-0a5c6c990d39
ORCID for R. Djukanovic: ORCID iD orcid.org/0000-0001-6039-5612

Catalogue record

Date deposited: 25 Apr 2006
Last modified: 06 Jun 2018 13:16

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