Polymorphisms in Toll-like receptor 4 and the systemic inflammatory response syndrome

Child, N.J.A., Yang, I.A., Pulletz, M.C.K., de Courcy-Golder, K., Andrews, A.-L., Pappachan, V.J. and Holloway, J.W. (2003) Polymorphisms in Toll-like receptor 4 and the systemic inflammatory response syndrome. Biochemical Society Transactions, 31 (3), 652-653.

Abstract

The systemic inflammatory response syndrome (SIRS) is a major cause of morbidity and mortality, and is thought to be due to an over-amplification of an inflammatory response. The Toll-like receptor 4 (TLR4) Asp-299?Gly polymorphism has been shown to reduce lipopolysaccharide responsiveness. We examined whether this TLR4 polymorphism is associated with severity of SIRS. A trend was found between the minor allele and mortality in SIRS (odds ratio of 4.3; P=0.076), suggesting a role for TLR4 signalling in the severity of SIRS.
Abbreviations: SIRS, systemic inflammatory response syndrome; TLR4, Toll-like receptor 4; ICU, intensive care unit; PRR, pattern recognition receptor; LPS, lipopolysaccharide; SNP, single nucleotide polymorphism; LOS, length of stay; APACHE II, acute physiological and chronic health evaluation; LIS, lung injury score; SOFA, sequential organ failure score; PaO?/FiO?, partial pressure of arterial oxygen/fraction of inspired oxygen.

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Contributors

Author: J.W. Holloway

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