Microdialysis of large molecules
Microdialysis of large molecules
Microdialysis has been used in many tissues, including skin, brain, adipose tissue, muscle, kidney, and gastrointestinal tract, to recover low–molecular mass endogenous mediators, metabolites, and xenobiotics from the interstitial space. Recently, molecules of larger molecular mass, such as plasma proteins, cytokines, growth factors, and neuropeptides, have also been recovered successfully using larger-pore membranes. Microdialysis recovery of large molecules offers the opportunity to identify patterns of protein expression in a variety of tissue spaces and to evaluate clinically useful biomarkers of disease. From this may develop a better understanding of the disease process and its diagnosis and more targeted approaches to therapy.
microdialysis, proteins, cytokines
E686-E692
Clough, Geraldine F.
9f19639e-a929-4976-ac35-259f9011c494
2005
Clough, Geraldine F.
9f19639e-a929-4976-ac35-259f9011c494
Clough, Geraldine F.
(2005)
Microdialysis of large molecules.
The AAPS Journal, 7 (3), .
(doi:10.1208/aapsj070369).
Abstract
Microdialysis has been used in many tissues, including skin, brain, adipose tissue, muscle, kidney, and gastrointestinal tract, to recover low–molecular mass endogenous mediators, metabolites, and xenobiotics from the interstitial space. Recently, molecules of larger molecular mass, such as plasma proteins, cytokines, growth factors, and neuropeptides, have also been recovered successfully using larger-pore membranes. Microdialysis recovery of large molecules offers the opportunity to identify patterns of protein expression in a variety of tissue spaces and to evaluate clinically useful biomarkers of disease. From this may develop a better understanding of the disease process and its diagnosis and more targeted approaches to therapy.
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Published date: 2005
Keywords:
microdialysis, proteins, cytokines
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Local EPrints ID: 26996
URI: http://eprints.soton.ac.uk/id/eprint/26996
ISSN: 1550-7416
PURE UUID: 0d15bec5-e152-47b7-9250-9f982f986603
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Date deposited: 27 Apr 2006
Last modified: 16 Mar 2024 02:54
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