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Treatment of resistant pemphigus vulgaris with an anti-CD20 monoclonal antibody (Rituximab)

Treatment of resistant pemphigus vulgaris with an anti-CD20 monoclonal antibody (Rituximab)
Treatment of resistant pemphigus vulgaris with an anti-CD20 monoclonal antibody (Rituximab)
We describe a 54-year-old man with resistant pemphigus vulgaris. Standard therapies had afforded inadequate control and have been associated with considerable side-effects. The anti-CD20 monoclonal antibody, Rituximab (MabThera, Roche), was trialled with significant benefit. We discuss its potential mechanism of action.
0307-6938
366-368
Cooper, H.L.
80852309-f99f-4024-a4d7-71ba0342261a
Healy, E.
400fc04d-f81a-474a-ae25-7ff894be0ebd
Theaker, J.M.
e24ec934-c79c-471c-8556-d38a15ac845b
Friedmann, P.S.
d50bac23-f3ec-4493-8fa0-fa126cbeba88
Cooper, H.L.
80852309-f99f-4024-a4d7-71ba0342261a
Healy, E.
400fc04d-f81a-474a-ae25-7ff894be0ebd
Theaker, J.M.
e24ec934-c79c-471c-8556-d38a15ac845b
Friedmann, P.S.
d50bac23-f3ec-4493-8fa0-fa126cbeba88

Cooper, H.L., Healy, E., Theaker, J.M. and Friedmann, P.S. (2003) Treatment of resistant pemphigus vulgaris with an anti-CD20 monoclonal antibody (Rituximab). Clinical and Experimental Dermatology, 28 (4), 366-368. (doi:10.1046/j.1365-2230.2003.01283.x).

Record type: Article

Abstract

We describe a 54-year-old man with resistant pemphigus vulgaris. Standard therapies had afforded inadequate control and have been associated with considerable side-effects. The anti-CD20 monoclonal antibody, Rituximab (MabThera, Roche), was trialled with significant benefit. We discuss its potential mechanism of action.

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Published date: July 2003

Identifiers

Local EPrints ID: 27003
URI: http://eprints.soton.ac.uk/id/eprint/27003
ISSN: 0307-6938
PURE UUID: cf492800-318f-407d-ba2f-3ffc8e2210e6

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Date deposited: 26 Apr 2006
Last modified: 15 Mar 2024 07:14

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Contributors

Author: H.L. Cooper
Author: E. Healy
Author: J.M. Theaker
Author: P.S. Friedmann

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