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The relationship between atopic status and IL-10 nasal lavage levels in the acute and persistent inflammatory response to upper respiratory tract infection

Record type: Article

We examined the influence of atopy on virus-induced airway inflammation by comparing the nasal response to naturally acquired upper respiratory tract infection in atopic and nonatopic subjects by measurement of cytokine, chemokine, and mediator levels in nasal lavage from 44 adults (23 atopic) taken during the acute and the convalescent phases of the common cold.
Nasal aspirates were examined for the presence of upper respiratory viruses by RT-PCR. In atopic and nonatopic subjects there were increased levels of IL-1, IL-6, IL-8, TNF-, RANTES, sICAM-1, MPO, ECP, IL-10, and IFN- in nasal lavage during the acute compared with the convalescent phase (p < 0.001). During the acute phase histamine levels were significantly higher in the atopic than in the nonatopic subjects (p < 0.05), whereas IL-10 levels were significantly greater in the nonatopic than in the atopic subjects (p < 0.05). At convalescence levels of IL-1, IL-6, sICAM-1, ECP, RANTES and albumin were significantly higher in the atopic group (p < 0.05). An upper respiratory tract virus was found in 27 volunteers (61%) during the acute stage and in two volunteers (4%) at convalescence. We conclude that virus-induced inflammatory changes within the nose are more prolonged in atopic than in nonatopic subjects and that this is associated with reduced IL-10 levels in atopic compared with nonatopic subjects during the acute phase of upper respiratory tract infection.

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Citation

Corne, Jonathan M., Lau, Laurie, Scott, Stephen J., Davies, Rhys, Johnston, Sebastian L. and Howarth, Peter H. (2001) The relationship between atopic status and IL-10 nasal lavage levels in the acute and persistent inflammatory response to upper respiratory tract infection American Journal of Respiratory and Critical Care Medicine, 163, (5), pp. 1101-1107.

More information

Published date: 2001

Identifiers

Local EPrints ID: 27005
URI: http://eprints.soton.ac.uk/id/eprint/27005
ISSN: 1073-449X
PURE UUID: 7ecea3ec-b033-4dc3-9f78-823d6bde4eaa

Catalogue record

Date deposited: 25 Apr 2006
Last modified: 17 Jul 2017 16:05

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Contributors

Author: Jonathan M. Corne
Author: Laurie Lau
Author: Stephen J. Scott
Author: Rhys Davies
Author: Sebastian L. Johnston

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