The University of Southampton
University of Southampton Institutional Repository

Discontinuation of pegylated interferon plus ribavirin in patients who are not responding to therapy - patients' views of early cessation of therapy

D'Souza, R., Main, J., Crossey, M., Rosenberg, W., Murray-Lyon, I.M., Hayward, C. and Foster, G.R. (2005) Discontinuation of pegylated interferon plus ribavirin in patients who are not responding to therapy - patients' views of early cessation of therapy Alimentary Pharmacology & Therapeutics, 21, (1), pp. 43-47. (doi:10.1111/j.1365-2036.2004.02295.x).

Record type: Article


Background: Current therapy for chronic hepatitis C infection involves a course of pegylated interferon and ribavirin. Patients who do not show a virological response after 12 weeks of therapy have a low probability of sustained virological response and it is therefore recommended that such patients stop treatment.
Aim: To assess patients' views of early treatment cessation.
Methods: We conducted a open-labelled study in three UK centres, in which patients with biopsy-proven chronic hepatitis C requiring therapy were offered the choice of a full course of therapy with 40 kDa pegylated interferon-? 2a plus ribavirin (24 or 48 weeks depending on viral genotype) or early cessation if therapy had failed after 12 weeks.
Results: Ninety-five participants were enrolled and the majority (69%) did not wish to discontinue therapy even if it had low probability of success. In this unselected UK population, very few patients (4%) did not achieve an early virological response with the 40-kDa pegylated interferon-? 2a plus ribavirin and two of the four early virological non-responders decided to continue therapy.
Conclusion: Early discontinuation of 'ineffective' anti-viral therapy may prove less popular with patients than with health care providers, and further patient-directed education regarding the cost-effectiveness of therapy will be needed if early discontinuation of unsuccessful therapy is to be accepted by patients.

Full text not available from this repository.

More information

Published date: 2005


Local EPrints ID: 27010
ISSN: 0269-2813
PURE UUID: e1643db3-332f-4c10-8672-39b346a6ca56

Catalogue record

Date deposited: 25 Apr 2006
Last modified: 17 Jul 2017 16:05

Export record



Author: R. D'Souza
Author: J. Main
Author: M. Crossey
Author: W. Rosenberg
Author: I.M. Murray-Lyon
Author: C. Hayward
Author: G.R. Foster

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton:

ePrints Soton supports OAI 2.0 with a base URL of

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.