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The bronchial epithelium: translating gene and environment interactions in asthma

The bronchial epithelium: translating gene and environment interactions in asthma
The bronchial epithelium: translating gene and environment interactions in asthma
The rising trends in asthma over the past 30 years are likely to be a consequence of changes in the environment acting on a susceptible genotype. Recognising that environmental agents impact on the bronchial epithelium, this structure is in a key position to translate and coordinate these gene-environment interactions. In asthma, the bronchial epithelium is stressed and damaged, with shedding of the columnar cells into the airway lumen. The aim of this review is to consider recent advances in our understanding of why the epithelium is damaged and how the ensuing repair responses orchestrate airway inflammation and remodelling leading to the development and maintenance of the asthmatic state.
1528-4050
67-71
Davies, Donna E.
7de8fdc7-3640-4e3a-aa91-d0e03f990c38
Davies, Donna E.
7de8fdc7-3640-4e3a-aa91-d0e03f990c38

Davies, Donna E. (2001) The bronchial epithelium: translating gene and environment interactions in asthma. Current Opinion in Allergy and Clinical Immunology, 1 (1), 67-71.

Record type: Article

Abstract

The rising trends in asthma over the past 30 years are likely to be a consequence of changes in the environment acting on a susceptible genotype. Recognising that environmental agents impact on the bronchial epithelium, this structure is in a key position to translate and coordinate these gene-environment interactions. In asthma, the bronchial epithelium is stressed and damaged, with shedding of the columnar cells into the airway lumen. The aim of this review is to consider recent advances in our understanding of why the epithelium is damaged and how the ensuing repair responses orchestrate airway inflammation and remodelling leading to the development and maintenance of the asthmatic state.

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Published date: 2001

Identifiers

Local EPrints ID: 27012
URI: https://eprints.soton.ac.uk/id/eprint/27012
ISSN: 1528-4050
PURE UUID: c735d9d4-2378-499c-9e85-38f8d0cca0b5
ORCID for Donna E. Davies: ORCID iD orcid.org/0000-0002-5117-2991

Catalogue record

Date deposited: 26 Apr 2006
Last modified: 20 Jul 2019 01:28

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