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Letter to the editor: Sodium cromoglycate in childhood asthma

Letter to the editor: Sodium cromoglycate in childhood asthma
Letter to the editor: Sodium cromoglycate in childhood asthma
The review of placebo controlled trials of sodium cromoglycate (SCG) in childhood asthma by Tasche et al1 concludes that "there is insufficient evidence that SCG has a beneficial effect as maintenance treatment in children with asthma".
We do not believe this conclusion is justified. The principal criteria for assessing the efficacy of inhaled SCG are the mean differences in the effect on the symptoms of cough and wheeze between SCG and placebo across all trials included in the review. The 95% confidence intervals for these differences are 0.12 to 0.27 for cough and 0.11 to 0.26 for wheeze. As the differences are in favour of SCG and the confidence intervals do not include zero, the only conclusion that can be drawn is that there is strong statistical evidence for a beneficial effect of SCG in children with asthma---the reverse conclusion to that presented.
0040-6376
331-332
Edwards, A.
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Holgate, S.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Howell, J.
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Warner, J.
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Stevens, M.
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Åberg, N.
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Callaghan, B.
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Ikura, Y.
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König, P.
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Reinhardt, D.
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Stenius-Aarniala, B.
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Weinberg, E.
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Edwards, A.
59c01056-ed68-421d-9535-a5c77f3dd0ec
Holgate, S.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Howell, J.
bb63789c-0189-4f3d-9a50-539648d55ead
Warner, J.
8571b049-31bb-4a2a-a3c7-4184be20fe25
Stevens, M.
3f780585-94de-4a4c-bc5e-623fae757516
Åberg, N.
dde22ae2-efbd-4a92-b4ca-bd3f5d4039d2
Callaghan, B.
4c90b13a-cd17-40ba-b9fd-c7f7d35313ef
Ikura, Y.
838cadae-901b-4c13-9538-b955a109c56c
König, P.
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Reinhardt, D.
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Stenius-Aarniala, B.
9bfc5f7b-79e2-4758-b1c8-1c24bbf6c585
Weinberg, E.
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Edwards, A., Holgate, S., Howell, J., Warner, J., Stevens, M., Åberg, N., Callaghan, B., Ikura, Y., König, P., Reinhardt, D., Stenius-Aarniala, B. and Weinberg, E. (2001) Letter to the editor: Sodium cromoglycate in childhood asthma. Thorax, 56 (4), 331-332.

Record type: Article

Abstract

The review of placebo controlled trials of sodium cromoglycate (SCG) in childhood asthma by Tasche et al1 concludes that "there is insufficient evidence that SCG has a beneficial effect as maintenance treatment in children with asthma".
We do not believe this conclusion is justified. The principal criteria for assessing the efficacy of inhaled SCG are the mean differences in the effect on the symptoms of cough and wheeze between SCG and placebo across all trials included in the review. The 95% confidence intervals for these differences are 0.12 to 0.27 for cough and 0.11 to 0.26 for wheeze. As the differences are in favour of SCG and the confidence intervals do not include zero, the only conclusion that can be drawn is that there is strong statistical evidence for a beneficial effect of SCG in children with asthma---the reverse conclusion to that presented.

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Published date: 2001
Additional Information: letter to the editor

Identifiers

Local EPrints ID: 27036
URI: https://eprints.soton.ac.uk/id/eprint/27036
ISSN: 0040-6376
PURE UUID: b7583422-3c82-4883-8ea6-8f5ee0fe2144

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Date deposited: 25 Apr 2006
Last modified: 17 Jul 2017 16:05

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Contributors

Author: A. Edwards
Author: S. Holgate
Author: J. Howell
Author: J. Warner
Author: M. Stevens
Author: N. Åberg
Author: B. Callaghan
Author: Y. Ikura
Author: P. König
Author: D. Reinhardt
Author: B. Stenius-Aarniala
Author: E. Weinberg

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