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Regulation of cellular processes by PPAR? ligands in neuroblastoma cells is modulated by the level of retinoblastoma protein expression

Record type: Article

Neuroblastoma is a childhood cancer, which spontaneously regresses. This has led to a search for agents that mimic this process. We show that both natural and synthetic ligands of PPAR? (peroxisome-proliferator-activated receptor ?) inhibit the growth of neuroblastoma cells in vitro. The degree of PPAR activation was attenuated however in the presence of the retinoblastoma protein. Addition of trichostatin A, a histone deacetylase inhibitor, abolished retinoblastoma protein repression of PPAR activity. Moreover, enhanced growth inhibition was observed when neuroblastoma cells were treated with a PPAR? ligand and a histone deacetylase inhibitor, suggesting a combination therapy to treat neuroblastoma might prove more effective than using either agent alone.

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Citation

Emmans, V.C., Rodway, H.A., Hunt, A.N. and Lillycrop, K.A. (2004) Regulation of cellular processes by PPAR? ligands in neuroblastoma cells is modulated by the level of retinoblastoma protein expression Biochemical Society Transactions, 32, pp. 840-842.

More information

Published date: 2004
Keywords: cancer, neuroblastoma cells, nuclear receptor, peroxisome-proliferator-activated receptor ? (ppar?), retinoblastoma protein, transcription

Identifiers

Local EPrints ID: 27039
URI: http://eprints.soton.ac.uk/id/eprint/27039
ISSN: 0300-5127
PURE UUID: cae0f30d-074b-46b3-8e05-fcc5d6762eb7
ORCID for A.N. Hunt: ORCID iD orcid.org/0000-0001-5938-2152
ORCID for K.A. Lillycrop: ORCID iD orcid.org/0000-0001-7350-5489

Catalogue record

Date deposited: 26 Apr 2006
Last modified: 17 Jul 2017 16:05

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