Emmans, V.C., Rodway, H.A., Hunt, A.N. and Lillycrop, K.A.
Regulation of cellular processes by PPAR? ligands in neuroblastoma cells is modulated by the level of retinoblastoma protein expression
Biochemical Society Transactions, 32, .
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Neuroblastoma is a childhood cancer, which spontaneously regresses. This has led to a search for agents that mimic this process. We show that both natural and synthetic ligands of PPAR? (peroxisome-proliferator-activated receptor ?) inhibit the growth of neuroblastoma cells in vitro. The degree of PPAR activation was attenuated however in the presence of the retinoblastoma protein. Addition of trichostatin A, a histone deacetylase inhibitor, abolished retinoblastoma protein repression of PPAR activity. Moreover, enhanced growth inhibition was observed when neuroblastoma cells were treated with a PPAR? ligand and a histone deacetylase inhibitor, suggesting a combination therapy to treat neuroblastoma might prove more effective than using either agent alone.
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